Biodegradable Lipids Enabling Rapidly Eliminated Lipid Nanoparticles for Systemic Delivery of RNAi Therapeutics

Martin A. Maier, Muthusamy Jayaraman, Shigeo Matsuda, +26

Molecular Therapy

Impact of enhanced metabolic stability on pharmacokinetics and pharmacodynamics of GalNAc–siRNA conjugates

Jayaprakash K. Nair, Husain Attarwala, Alfica Sehgal, +21

Nucleic Acids Research

Pharmaceutical ScienceMolecular BiologyGene DeliveryMedicinal ChemistryGalnac-sirna Conjugates +14

Biocompatible MoS2/PDA-RGD coating on titanium implant with antibacterial property via intrinsic ROS-independent oxidative stress and NIR irradiation

Yuan Zhang, Bailong Tao, Ye He, +8

Biomaterials

An essential role for the interferon-inducible, double-stranded RNA-activated protein kinase PKR in the tumor necrosis factor-induced apoptosis in U937 cells.

Maximus C.F. Yeung, Ju Liu, Allan Lau

Proceedings of the National Academy of Sciences

InflammationU937 CellsCytokineSignaling PathwayEssential Role +13

E3 ubiquitin ligase TRIM32 negatively regulates tumor suppressor p53 to promote tumorigenesis

Ju Liu, C. Zhang, Xingyu Wang, +5

Cell Death and Differentiation

OncologyCell RegulationMedicineTumor Suppressor P53Cancer Cell Biology +9

Improving dendritic cell vaccine immunogenicity by silencing PD-1 ligands using siRNA-lipid nanoparticles combined with antigen mRNA electroporation

Willemijn Hobo, Tatiana I. Novobrantseva, Hanny Fredrix, +7

Cancer Immunology Immunotherapy

VaccinationNanomedicineCross-protectionEngineeringPd-1 Ligands +10

Ectopic Notch Activation in Developing Podocytes Causes Glomerulosclerosis

Aoife Waters, Megan Wu, Tuncer Onay, +5

Journal of the American Society of Nephrology

Glomerular DiseaseNephrologyOrgan DevelopmentCellular PhysiologyGlomerulonephritis +16

Plasmalemma vesicle-associated protein: A crucial component of vascular homeostasis

Ling Guo, Hongyan Zhang, Yinglong Hou, +2

Experimental and Therapeutic Medicine

Vascular DiseaseVasculitisImmunologyCellular PhysiologyInflammation +19

TLR4 participates in sympathetic hyperactivity Post-MI in the PVN by regulating NF-κB pathway and ROS production

Yu Wang, Hesheng Hu, Jie Yin, +13

Redox Biology

ImmunologyImmune RegulationRos ProductionDisease PhysiologyNeuroinflammation +19

MFG-E8 accelerates wound healing in diabetes by regulating “NLRP3 inflammasome-neutrophil extracellular traps” axis

Wei Huang, Jinyu Jiao, Ju Liu, +11

Cell Death Discovery