Emma Kinghorn

Therapeutic dosing of an orally active, selective cathepsin S inhibitor suppresses disease in models of autoimmunity

Mark Baugh, Darcey Black, Paul Westwood et al. · Journal of Autoimmunity · 2011 · 72 citations

Rheumatology, Autoimmune Disease, Medicine +9

Design and optimization of a series of novel 2-cyano-pyrimidines as cathepsin K inhibitors

Zoran Ranković, Jiaqiang Cai, Jennifer Kerr et al. · Bioorganic & Medicinal Chemistry Letters · 2010 · 25 citations · Full text

Combinatorial Chemistry, Cathepsin K Inhibitors, Medicinal Chemistry +10

4-(3-Trifluoromethylphenyl)-pyrimidine-2-carbonitrile as cathepsin S inhibitors: N3, not N1 is critically important

Jiaqiang Cai, Xavier Fradera, Mario van Zeeland et al. · Bioorganic & Medicinal Chemistry Letters · 2010 · 21 citations · Full text

Medicinal Chemistry, Biochemistry, Medicine +11

Trifluoromethylphenyl as P2 for ketoamide-based cathepsin S inhibitors

Jiaqiang Cai, John Robinson, Simone Belshaw et al. · Bioorganic & Medicinal Chemistry Letters · 2010 · 18 citations · Full text

Medicinal Chemistry, Biochemistry, Medicine +5

6-Phenyl-1H-imidazo[4,5-c]pyridine-4-carbonitrile as cathepsin S inhibitors

Jiaqiang Cai, Mark Baugh, Darcey Black et al. · Bioorganic & Medicinal Chemistry Letters · 2010 · 17 citations · Full text

Medicinal Chemistry, Bioorganic Chemistry, Biochemistry +8