Therapeutic dosing of an orally active, selective cathepsin S inhibitor suppresses disease in models of autoimmunity

Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins.

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Adaptive Immune System, T-regulatory Cell, Cellular Immunology +19

IL-17 in synovial fluids from patients with rheumatoid arthritis is a potent stimulator of osteoclastogenesis

Shigeru Kotake, Nobuyuki Udagawa, Naoyuki Takahashi et al. · Journal of Clinical Investigation · 1999 · 1.7K citations · Full text

Sclerostin, Immunology, Osteoporosis +19

High Levels of IL-17 in Rheumatoid Arthritis Patients: IL-15 Triggers In Vitro IL-17 Production Via Cyclosporin A-Sensitive Mechanism

Maria Ziółkowska, Anna Koc, Grazyna Luszczykiewicz et al. · The Journal of Immunology · 2000 · 580 citations

Essential Role for Cathepsin S in MHC Class II–Associated Invariant Chain Processing and Peptide Loading

Richard J. Riese, Paula Wolf, Dieter Brömme et al. · Immunity · 1996 · 527 citations · Full text

Protein Function, Essential Role, Biochemistry +7

Cathepsin S Required for Normal MHC Class II Peptide Loading and Germinal Center Development

Guo‐Ping Shi, Jóse A. Villadangos, Glenn Dranoff et al. · Immunity · 1999 · 520 citations · Full text

Medicine, Peptide Library, Immunology +6