Allosteric Modulation of the Cannabinoid CB1 Receptor

M. R. Price, Gemma L. Baillie, Adèle Thomas, +14

Molecular Pharmacology

Therapeutic dosing of an orally active, selective cathepsin S inhibitor suppresses disease in models of autoimmunity

Mark Baugh, Darcey Black, Paul Westwood, +18

Journal of Autoimmunity

RheumatologyAutoimmune DiseaseMedicineImmunologyTherapeutic Dosing +7

Design, synthesis, and structure–activity relationships of indole-3-carboxamides as novel water soluble cannabinoid CB1 receptor agonists

Julia M. Adam, Jim Cairns, Wilson Caulfield, +18

MedChemComm

Pharmaceutical ScienceDrug TargetPain MedicineLead IdentificationPharmacotherapy +15

Fragment-based discovery of 6-substituted isoquinolin-1-amine based ROCK-I inhibitors

Peter C. Ray, Jane Wright, Julia Adam, +21

Bioorganic & Medicinal Chemistry Letters

Combinatorial ChemistryMedicinal ChemistryNatural SciencesMedicineOrganic Chemistry +5

Design and optimization of a series of novel 2-cyano-pyrimidines as cathepsin K inhibitors

Zoran Ranković, Jiaqiang Cai, Jennifer Kerr, +28

Bioorganic & Medicinal Chemistry Letters

Combinatorial ChemistryCathepsin K InhibitorsMedicinal ChemistryBioorganic ChemistryBiochemistry +8

4-(3-Trifluoromethylphenyl)-pyrimidine-2-carbonitrile as cathepsin S inhibitors: N3, not N1 is critically important

Jiaqiang Cai, Xavier Fradera, Mario van Zeeland, +12

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryBiochemistryMedicineNatural SciencesMechanism Of Action +9

Optimisation of 6-substituted isoquinolin-1-amine based ROCK-I inhibitors

Peter C. Ray, Jane Wright, Julia Adam, +16

Bioorganic & Medicinal Chemistry Letters

Combinatorial ChemistryMedicinal ChemistryNatural SciencesMedicineOrganic Chemistry +4

Trifluoromethylphenyl as P2 for ketoamide-based cathepsin S inhibitors

Jiaqiang Cai, John Robinson, Simone Belshaw, +21

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryBiochemistryMedicineNatural SciencesDrug Development +3

6-Phenyl-1H-imidazo[4,5-c]pyridine-4-carbonitrile as cathepsin S inhibitors

Jiaqiang Cai, Mark Baugh, Darcey Black, +27

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryBioorganic ChemistryBiochemistryNatural SciencesMedicine +6

Discovery of Orally Available and Brain Penetrant AEP Inhibitors

Daniela Krummenacher, Weiping He, Bernd Kuhn, +27

Journal of Medicinal Chemistry