Lany Ruslim

A selective small molecule inhibitor of c-Met kinase inhibits c-Met-dependent phenotypes in vitro and exhibits cytoreductive antitumor activity in vivo.

James G. Christensen, Randall Schreck, Jon Burrows et al. · PubMed · 2003 · 497 citations

Medicine, Oncology, Pharmacology +15

Amyloid precursor protein selective gamma-secretase inhibitors for treatment of Alzheimer's disease

Guriqbal S. Basi, Susanna S. Hemphill, Elizabeth Brigham et al. · Alzheimer s Research & Therapy · 2010 · 52 citations · Full text

Life Sciences, Neuroscience, Pharmacology +17

Selective and Brain‐Permeable Polo‐like Kinase‐2 (Plk‐2) Inhibitors That Reduce α‐Synuclein Phosphorylation in Rat Brain

Danielle L. Aubele, Roy K. Hom, Marc Adler et al. · ChemMedChem · 2013 · 49 citations

Life Sciences, Medicinal Chemistry, Pharmacology +12

Design of an orally efficacious hydroxyethylamine (HEA) BACE-1 inhibitor in a preclinical animal model

Anh P. Truong, G. Toth, Gary D. Probst et al. · Bioorganic & Medicinal Chemistry Letters · 2010 · 48 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +7

Highly selective c-Jun N-terminal kinase (JNK) 2 and 3 inhibitors with in vitro CNS-like pharmacokinetic properties prevent neurodegeneration

Gary D. Probst, Simeon Bowers, Jennifer M. Sealy et al. · Bioorganic & Medicinal Chemistry Letters · 2010 · 44 citations · Full text

Life Sciences, Neuroscience, Pharmacology +14