David L. Norton

Monoacidic Inhibitors of the Kelch-like ECH-Associated Protein 1: Nuclear Factor Erythroid 2-Related Factor 2 (KEAP1:NRF2) Protein–Protein Interaction with High Cell Potency Identified by Fragment-Based Discovery

Thomas G. Davies, William E. Wixted, Joseph E. Coyle et al. · Journal of Medicinal Chemistry · 2016 · 306 citations · Full text

Life Sciences, Medicinal Chemistry, Pharmacology +17

Structure–Activity and Structure–Conformation Relationships of Aryl Propionic Acid Inhibitors of the Kelch-like ECH-Associated Protein 1/Nuclear Factor Erythroid 2-Related Factor 2 (KEAP1/NRF2) Protein–Protein Interaction

Tom D. Heightman, James F. Callahan, Elisabetta Chiarparin et al. · Journal of Medicinal Chemistry · 2019 · 97 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Nitrous Oxide Plus Isoflurane Induces Apoptosis and Increases β-Amyloid Protein Levels

Zhen Yu, Yuanlin Dong, Xu Wu et al. · Anesthesiology · 2009 · 81 citations · Full text

Life Sciences, Neurobiology, Neuroscience +17

Fragment-Based Discovery of a Potent, Orally Bioavailable Inhibitor That Modulates the Phosphorylation and Catalytic Activity of ERK1/2

Tom D. Heightman, Valério Berdini, Hannah Braithwaite et al. · Journal of Medicinal Chemistry · 2018 · 66 citations · Full text

Pharmacy, Medicinal Chemistry, Oncology +16

Design and synthesis of dihydroisoquinolones for fragment-based drug discovery (FBDD)

Nick Palmer, Torren M. Peakman, David L. Norton et al. · Organic & Biomolecular Chemistry · 2015 · 52 citations · Full text

Pharmacy, Chemistry, Medicinal Chemistry +17