Shirley Yeh

PTC124 targets genetic disorders caused by nonsense mutations

Ellen Welch, Elisabeth R. Barton, Jin Zhuo et al. · Nature · 2007 · 1.1K citations

Mendelian Disorder, Genetic Disorder, Genetics +4

THE INTERACTION BETWEEN <i>TOXOPLASMA GONDII</i> AND MAMMALIAN CELLS

Thomas C. Jones, Shirley Yeh, James G. Hirsch · The Journal of Experimental Medicine · 1972 · 228 citations · Full text

Parasitic Disease, Immunology, Pathology +16

Small molecule splicing modifiers with systemic HTT-lowering activity

Anuradha Bhattacharyya, Christopher R. Trotta, Jana Narasimhan et al. · Nature Communications · 2021 · 83 citations · Full text

Transcriptional Regulation, Systems Biology, Neurodegenerative Diseases +15

Targeting of Hematologic Malignancies with PTC299, A Novel Potent Inhibitor of Dihydroorotate Dehydrogenase with Favorable Pharmaceutical Properties

Liangxian Cao, Marla Weetall, Christopher R. Trotta et al. · Molecular Cancer Therapeutics · 2018 · 77 citations

Pharmacokinetics, pharmacodynamics, and efficacy of a small-molecule<i>SMN2</i>splicing modifier in mouse models of spinal muscular atrophy

Xin Zhao, Zhihua Feng, Karen Ling et al. · Human Molecular Genetics · 2016 · 35 citations · Full text

Biomedical Research, Genetics, Rna Splicing +18