Christopher R. Trotta

PTC124 targets genetic disorders caused by nonsense mutations

Ellen Welch, Elisabeth R. Barton, Jin Zhuo et al. · Nature · 2007 · 1.1K citations

Life Sciences, Genetics, Molecular Genetics +8

CLP1 Founder Mutation Links tRNA Splicing and Maturation to Cerebellar Development and Neurodegeneration

Ashleigh E. Schaffer, Veerle Rc Eggens, Ahmet Okay Çağlayan et al. · Cell · 2014 · 283 citations · Full text

Life Sciences, Genetics, Neuroscience +17

Identification of a Human Endonuclease Complex Reveals a Link between tRNA Splicing and Pre-mRNA 3′ End Formation

Sergey Paushkin, Meenal Patel, Bansri Furia et al. · Cell · 2004 · 246 citations · Full text

Life Sciences, Genetics, Molecular Biology +16

The Yeast tRNA Splicing Endonuclease: A Tetrameric Enzyme with Two Active Site Subunits Homologous to the Archaeal tRNA Endonucleases

Christopher R. Trotta, Eric A. Arn, Scott W. Stevens et al. · Cell · 1997 · 242 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +9

Ataluren stimulates ribosomal selection of near-cognate tRNAs to promote nonsense suppression

Bijoyita Roy, Westley J. Friesen, Yuki Tomizawa et al. · Proceedings of the National Academy of Sciences · 2016 · 223 citations · Full text

Life Sciences, Genetics, Molecular Biology +17