Christopher R. Trotta

PTC124 targets genetic disorders caused by nonsense mutations

Ellen Welch, Elisabeth R. Barton, Jin Zhuo et al. · Nature · 2007 · 1.1K citations

Mendelian Disorder, Genetic Disorder, Genetics +4

CLP1 Founder Mutation Links tRNA Splicing and Maturation to Cerebellar Development and Neurodegeneration

Ashleigh E. Schaffer, Veerle Rc Eggens, Ahmet Okay Çağlayan et al. · Cell · 2014 · 280 citations · Full text

Identification of a Human Endonuclease Complex Reveals a Link between tRNA Splicing and Pre-mRNA 3′ End Formation

Sergey Paushkin, Meenal Patel, Bansri Furia et al. · Cell · 2004 · 245 citations · Full text

Transcriptional Regulation, Natural Sciences, Genetics +13

The Yeast tRNA Splicing Endonuclease: A Tetrameric Enzyme with Two Active Site Subunits Homologous to the Archaeal tRNA Endonucleases

Christopher R. Trotta, Miao Feng, Eric A. Arn et al. · Cell · 1997 · 240 citations · Full text

Biochemistry, Natural Sciences, Archaeal Trna Endonucleases +7

Ataluren stimulates ribosomal selection of near-cognate tRNAs to promote nonsense suppression

Bijoyita Roy, Westley J. Friesen, Yuki Tomizawa et al. · Proceedings of the National Academy of Sciences · 2016 · 221 citations · Full text