PTC124 targets genetic disorders caused by nonsense mutations

Ellen Welch, Elisabeth R. Barton, Jin Zhuo, +39

Nature

Mendelian DisorderGenetic DisorderGeneticsMolecular GeneticsNonsense Mutations +2

Ataluren stimulates ribosomal selection of near-cognate tRNAs to promote nonsense suppression

Bijoyita Roy, Westley J. Friesen, Yuki Tomizawa, +13

Proceedings of the National Academy of Sciences

Transcriptional repressor RST1 controls salt tolerance and grain yield in rice by regulating gene expression of asparagine synthetase

Ping Deng, Wen Jing, Chengjuan Cao, +18

Proceedings of the National Academy of Sciences

The nucleoside analog clitocine is a potent and efficacious readthrough agent

Westley J. Friesen, Christopher R. Trotta, Yuki Tomizawa, +16

RNA

Functional P53Premature Stop CodonMedicineGeneticsHormonal Receptor +13

The minor gentamicin complex component, X2, is a potent premature stop codon readthrough molecule with therapeutic potential

Westley J. Friesen, Briana Johnson, Jairo Sierra, +18

PLoS ONE

Vascularized bone regeneration accelerated by 3D-printed nanosilicate-functionalized polycaprolactone scaffold

Xiongcheng Xu, Long Xiao, Yanmei Xu, +10

Regenerative Biomaterials

Length Changes in the Joining Segment between Domains 5 and 6 of a Group II Intron Inhibit Self-Splicing and Alter 3′ Splice Site Selection

Scott C. Boulanger, Peggy Ho Faix, Haiyan Yang, +4

Molecular and Cellular Biology

Domain 5 binds near a highly conserved dinucleotide in the joiner linking domains 2 and 3 of a group II intron.

Mircea Podar, Jin Zhuo, Mincheng Zhang, +3

PubMed

Protein AssemblyStructural BioinformaticsGeneticsMolecular BiologyMolecular Genetics +18

A Conjugation-Based System for Genetic Analysis of Group II Intron Splicing in<i>Lactococcus lactis</i>

Joanna R. Klein, Yuqing Chen, Dawn A. Manias, +4

Journal of Bacteriology

Genetic AnalysisConjugation-based SystemLtrb GeneGeneticsBacteriology +10

Tuning osteoporotic macrophage responses to favour regeneration by Cu-bearing titanium alloy in<i>Porphyromonas gingivalis</i>lipopolysaccharide-induced microenvironments

Xiongcheng Xu, Yanjin Lu, Ling Zhou, +5

Regenerative Biomaterials