Paul A. Tuthill

Design, synthesis, and kinetic evaluation of a unique class of elastase inhibitors, the peptidyl .alpha.-ketobenzoxazoles, and the x-ray crystal structure of the covalent complex between porcine pancreatic elastase and Ac-Ala-Pro-Val-2-benzoxazole

Philip D. Edwards, Edgar F. Meyer, J. Vijayalakshmi et al. · Journal of the American Chemical Society · 1992 · 144 citations

Pharmacy, Chemistry, Pharmacology +10

Potent, Orally Bioavailable Delta Opioid Receptor Agonists for the Treatment of Pain: Discovery of<i>N</i>,<i>N</i>-Diethyl-4-(5-hydroxyspiro[chromene-2,4′-piperidine]-4-yl)benzamide (ADL5859)

Bertrand Le Bourdonnec, Rolf T. Windh, Christopher W. Ajello et al. · Journal of Medicinal Chemistry · 2008 · 90 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Spirocyclic Delta Opioid Receptor Agonists for the Treatment of Pain: Discovery of<i>N</i>,<i>N</i>-Diethyl-3-hydroxy-4-(spiro[chromene-2,4′-piperidine]-4-yl) Benzamide (ADL5747)

Bertrand Le Bourdonnec, Rolf T. Windh, Lara K. Leister et al. · Journal of Medicinal Chemistry · 2009 · 85 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +13

Antinociceptive activity of the selective iNOS inhibitor AR‐C102222 in rodent models of inflammatory, neuropathic and post‐operative pain

Christopher J. LaBuda, Michael Koblish, Paul A. Tuthill et al. · European Journal of Pain · 2005 · 67 citations

Nursing, Anesthesiology, Pharmacology +17

Discovery and Biological Activity of Orally Active Peptidyl Trifluoromethyl Ketone Inhibitors of Human Neutrophil Elastase

Philip D. Edwards, Donald W. Andisik, Craig A. Bryant et al. · Journal of Medicinal Chemistry · 1997 · 51 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +13