Michael Koblish

A G Protein-Biased Ligand at the μ-Opioid Receptor Is Potently Analgesic with Reduced Gastrointestinal and Respiratory Dysfunction Compared with Morphine

Scott M. DeWire, Dennis S. Yamashita, David H. Rominger et al. · Journal of Pharmacology and Experimental Therapeutics · 2013 · 655 citations

Medicine, Medicinal Chemistry, Pharmacology +17

Structure–Activity Relationships and Discovery of a G Protein Biased μ Opioid Receptor Ligand, [(3-Methoxythiophen-2-yl)methyl]({2-[(9<i>R</i>)-9-(pyridin-2-yl)-6-oxaspiro-[4.5]decan-9-yl]ethyl})amine (TRV130), for the Treatment of Acute Severe Pain

Xiaotao Chen, Philip Pitis, Guodong Liu et al. · Journal of Medicinal Chemistry · 2013 · 203 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +17

Potent, Orally Bioavailable Delta Opioid Receptor Agonists for the Treatment of Pain: Discovery of<i>N</i>,<i>N</i>-Diethyl-4-(5-hydroxyspiro[chromene-2,4′-piperidine]-4-yl)benzamide (ADL5859)

Bertrand Le Bourdonnec, Rolf T. Windh, Christopher W. Ajello et al. · Journal of Medicinal Chemistry · 2008 · 90 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Spirocyclic Delta Opioid Receptor Agonists for the Treatment of Pain: Discovery of<i>N</i>,<i>N</i>-Diethyl-3-hydroxy-4-(spiro[chromene-2,4′-piperidine]-4-yl) Benzamide (ADL5747)

Bertrand Le Bourdonnec, Rolf T. Windh, Lara K. Leister et al. · Journal of Medicinal Chemistry · 2009 · 85 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +13

Cannabinoid CB2 receptor agonist activity in the hindpaw incision

Christopher J. LaBuda, Michael Koblish, Patrick Little · European Journal of Pharmacology · 2005 · 74 citations

Medicine, Pharmacology, Neuropharmacology +5