Philip Pitis

A G Protein-Biased Ligand at the μ-Opioid Receptor Is Potently Analgesic with Reduced Gastrointestinal and Respiratory Dysfunction Compared with Morphine

Scott M. DeWire, Dennis S. Yamashita, David H. Rominger et al. · Journal of Pharmacology and Experimental Therapeutics · 2013 · 630 citations

Structure–Activity Relationships and Discovery of a G Protein Biased μ Opioid Receptor Ligand, [(3-Methoxythiophen-2-yl)methyl]({2-[(9<i>R</i>)-9-(pyridin-2-yl)-6-oxaspiro-[4.5]decan-9-yl]ethyl})amine (TRV130), for the Treatment of Acute Severe Pain

Xiaotao Chen, Philip Pitis, Guodong Liu et al. · Journal of Medicinal Chemistry · 2013 · 193 citations · Full text

Aroyl(aminoacyl)pyrroles, a New Class of Anticonvulsant Agents

John R. Carson, R. Carmosin, Philip Pitis et al. · Journal of Medicinal Chemistry · 1997 · 57 citations

Medicinal Chemistry, Seizure Threshold, Type 9 +13

Parallel methods for the preparation and SAR exploration of N-ethyl-4-[(8-alkyl-8-aza-bicyclo[3.2.1]oct-3-ylidene)-aryl-methyl]-benzamides, powerful mu and delta opioid agonists

Steven J. Coats, Mark J. Schulz, John R. Carson et al. · Bioorganic & Medicinal Chemistry Letters · 2004 · 28 citations · Full text

Sar Exploration, Combinatorial Chemistry, Medicinal Chemistry +13

N , N -Dialkyl-4-[(8-azabicyclo[3.2.1]-oct-3-ylidene)phenylmethyl]benzamides, potent, selective δ opioid agonists

John R. Carson, Steven J. Coats, Ellen E. Codd et al. · Bioorganic & Medicinal Chemistry Letters · 2004 · 19 citations · Full text

Molecular Pharmacology, Medicinal Chemistry, Medicine +7