Raphaël Frédérick

Reversal of tumoral immune resistance by inhibition of tryptophan 2,3-dioxygenase

Luc Pilotte, Pierre Larrieu, Vincent Stroobant et al. · Proceedings of the National Academy of Sciences · 2012 · 570 citations · Full text

Medicine, Oncology, Pharmacology +14

Lactate Dehydrogenase B Controls Lysosome Activity and Autophagy in Cancer

Lucie Brisson, Piotr Bański, Martina Sboarina et al. · Cancer Cell · 2016 · 232 citations · Full text

Life Sciences, Cancer Biology, Oncology +10

Tryptophan 2,3-Dioxygenase (TDO) Inhibitors. 3-(2-(Pyridyl)ethenyl)indoles as Potential Anticancer Immunomodulators

Eduard Dolušić, Pierre Larrieu, Laurence Moineaux et al. · Journal of Medicinal Chemistry · 2011 · 182 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +14

Tryptophan depletion sensitizes the AHR pathway by increasing AHR expression and GCN2/LAT1-mediated kynurenine uptake, and potentiates induction of regulatory T lymphocytes

Marie Solvay, Simon Klaessens, Luc Pilotte et al. · Journal for ImmunoTherapy of Cancer · 2023 · 112 citations · Full text

Life Sciences, Immunology, Pharmacology +8

Synthesis and Biological Evaluation of Novel Analogues of the Pan Class I Phosphatidylinositol 3-Kinase (PI3K) Inhibitor 2-(Difluoromethyl)-1-[4,6-di(4-morpholinyl)-1,3,5-triazin-2-yl]-1<i>H</i>-benzimidazole (ZSTK474)

Gordon W. Rewcastle, Swarna A. Gamage, Jack U. Flanagan et al. · Journal of Medicinal Chemistry · 2011 · 103 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +15