Simon Klaessens

Tryptophan depletion sensitizes the AHR pathway by increasing AHR expression and GCN2/LAT1-mediated kynurenine uptake, and potentiates induction of regulatory T lymphocytes

Marie Solvay, Simon Klaessens, Luc Pilotte et al. · Journal for ImmunoTherapy of Cancer · 2023 · 81 citations · Full text

A novel cancer-germline transcript carrying pro-metastatic miR-105 and<i>TET</i>-targeting miR-767 induced by DNA hypomethylation in tumors

Axelle Loriot, Aurélie Van Tongelen, Jordi Blanco et al. · Epigenetics · 2014 · 67 citations · Full text

Engineering, Dna Hypomethylation-dependent Activation, Cancer Biology +20

Tryptophan 2,3-Dioxygenase Expression Identified in Human Hepatocellular Carcinoma Cells and in Intratumoral Pericytes of Most Cancers

Delia Hoffmann, Tereza Dvořáková, Vincent Stroobant et al. · Cancer Immunology Research · 2019 · 54 citations · Full text

Tryptophanemia is controlled by a tryptophan-sensing mechanism ubiquitinating tryptophan 2,3-dioxygenase

Simon Klaessens, Vincent Stroobant, Delia Hoffmann et al. · Proceedings of the National Academy of Sciences · 2021 · 18 citations · Full text

Rational Design of Original Fused-Cycle Selective Inhibitors of Tryptophan 2,3-Dioxygenase

Arina Kozlova, Léopold Thabault, Maxime Liberelle et al. · Journal of Medicinal Chemistry · 2021 · 17 citations · Full text