Evidence for a tumoral immune resistance mechanism based on tryptophan degradation by indoleamine 2,3-dioxygenase

Catherine Uyttenhove, Luc Pilotte, Ivan Théate, +5

Nature Medicine

InflammationCancer ImmunosurveillanceBiochemistryImmunologyTumor Immunity +6

Reversal of tumoral immune resistance by inhibition of tryptophan 2,3-dioxygenase

Luc Pilotte, Pierre Larrieu, Vincent Stroobant, +8

Proceedings of the National Academy of Sciences

ImmunotoxicologyImmunologyImmunoeditingCell DeathImmunotherapy +16

Extensive Profiling of the Expression of the Indoleamine 2,3-Dioxygenase 1 Protein in Normal and Tumoral Human Tissues

Ivan Théate, Nicolas van Baren, Luc Pilotte, +8

Cancer Immunology Research

ImmunologyImmunoeditingPathologyImmunologic MechanismImmunotherapy +19

Tryptophan 2,3-Dioxygenase (TDO) Inhibitors. 3-(2-(Pyridyl)ethenyl)indoles as Potential Anticancer Immunomodulators

Eduard Dolušić, Pierre Larrieu, Laurence Moineaux, +8

Journal of Medicinal Chemistry

ImmunologyTryptophan DegradationCell DeathPharmaceutical ChemistryMolecular Pharmacology +17

Constitutive IDO1 Expression in Human Tumors Is Driven by Cyclooxygenase-2 and Mediates Intrinsic Immune Resistance

Marc Hennequart, Luc Pilotte, Stefania Canè, +4

Cancer Immunology Research

Rational Design of 4-Aryl-1,2,3-Triazoles for Indoleamine 2,3-Dioxygenase 1 Inhibition

Ute F. Röhrig, Somi Reddy Majjigapu, Aurélien Grosdidier, +8

Journal of Medicinal Chemistry

Tryptophan depletion sensitizes the AHR pathway by increasing AHR expression and GCN2/LAT1-mediated kynurenine uptake, and potentiates induction of regulatory T lymphocytes

Marie Solvay, Simon Klaessens, Luc Pilotte, +10

Journal for ImmunoTherapy of Cancer

Deficiency of immunoregulatory indoleamine 2,3-dioxygenase 1in juvenile diabetes

Ciriana Orabona, Giada Mondanelli, Maria Teresa Pallotta, +32

JCI Insight

Detailed analysis and follow-up studies of a high-throughput screening for indoleamine 2,3-dioxygenase 1 (IDO1) inhibitors

Ute F. Röhrig, Somi Reddy Majjigapu, Marc Chambon, +8

European Journal of Medicinal Chemistry

Medicinal ChemistryBiochemistryMedicineNatural SciencesIndoleamine 2,3-Dioxygenase 1 +5

Inhibition of Tryptophan-Dioxygenase Activity Increases the Antitumor Efficacy of Immune Checkpoint Inhibitors

Florence Schramme, Stefano Crosignani, Kim Frederix, +6

Cancer Immunology Research