Jack U. Flanagan

Targeting GLUT1 and the Warburg Effect in Renal Cell Carcinoma by Chemical Synthetic Lethality

Denise A. Chan, Patrick D. Sutphin, Phuong Nguyen et al. · Science Translational Medicine · 2011 · 569 citations

A drug targeting only p110α can block phosphoinositide 3-kinase signalling and tumour growth in certain cell types

Stephen M. F. Jamieson, Jack U. Flanagan, Sharada Kolekar et al. · Biochemical Journal · 2011 · 170 citations · Full text

Tumour Growth, Cancer Biology, Responsive Cell Lines +21

Human theta class glutathione transferase: the crystal structure reveals a sulfate-binding pocket within a buried active site

Jamie Rossjohn, William J. McKinstry, Aaron J. Oakley et al. · Structure · 1998 · 158 citations · Full text

Crystal Structure, Buried Active Site, Biochemistry +9

Binding mode of the breakthrough inhibitor AZD9291 to epidermal growth factor receptor revealed

Y. Yosaatmadja, Shevan Silva, James M. Dickson et al. · Journal of Structural Biology · 2015 · 145 citations

Signal Transduction, Signaling Pathway, G Protein-coupled Receptor +9

Selenium-containing green tea has higher antioxidant and prebiotic activities than regular green tea

A.L. Molan, Jack U. Flanagan, Wenhua Wei et al. · Food Chemistry · 2008 · 141 citations

Polyphenolics, Food Bioactive Compound, Selenium Deficiency +6