Jessica Schmitt

Structure-Based Design of Orally Bioavailable 1<i>H</i>-Pyrrolo[3,2-<i>c</i>]pyridine Inhibitors of Mitotic Kinase Monopolar Spindle 1 (MPS1)

Sébastien Naud, Isaac M. Westwood, Amir Faisal et al. · Journal of Medicinal Chemistry · 2013 · 79 citations · Full text

Pharmacy, Medicinal Chemistry, Oncology +15

Aurora Isoform Selectivity: Design and Synthesis of Imidazo[4,5-<i>b</i>]pyridine Derivatives as Highly Selective Inhibitors of Aurora-A Kinase in Cells

Vassilios Bavetsias, Amir Faisal, Simon Crumpler et al. · Journal of Medicinal Chemistry · 2013 · 78 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +13

Introduction of a Methyl Group Curbs Metabolism of Pyrido[3,4-<i>d</i>]pyrimidine Monopolar Spindle 1 (MPS1) Inhibitors and Enables the Discovery of the Phase 1 Clinical Candidate <i>N</i>²-(2-Ethoxy-4-(4-methyl-4<i>H</i>-1,2,4-triazol-3-yl)phenyl)-6-methyl-<i>N</i>⁸-neopentylpyrido[3,4-<i>d</i>]pyrimidine-2,8-diamine (BOS172722)

Hannah L. Woodward, Paolo Innocenti, Kwai-Ming J. Cheung et al. · Journal of Medicinal Chemistry · 2018 · 33 citations · Full text

Medicine, Oncology, Pharmacology +15

Naturally Occurring Mutations in the <i>MPS1</i> Gene Predispose Cells to Kinase Inhibitor Drug Resistance

Mark D. Gurden, Isaac M. Westwood, Amir Faisal et al. · Cancer Research · 2015 · 32 citations

Medicine, Oncology, Pharmacology +14

Rapid Discovery of Pyrido[3,4-<i>d</i>]pyrimidine Inhibitors of Monopolar Spindle Kinase 1 (MPS1) Using a Structure-Based Hybridization Approach

Paolo Innocenti, Hannah L. Woodward, Savade Solanki et al. · Journal of Medicinal Chemistry · 2016 · 32 citations · Full text

Pharmacy, Medicinal Chemistry, Oncology +15