Hannah L. Woodward

Discovery of Novel Small-Molecule Inhibitors of BRD4 Using Structure-Based Virtual Screening

Lewis R. Vidler, P. Filippakopoulos, O. Fedorov et al. · Journal of Medicinal Chemistry · 2013 · 126 citations · Full text

Combinatorial Chemistry, Crystal Structure, Drug Target +19

Achieving <i>In Vivo</i> Target Depletion through the Discovery and Optimization of Benzimidazolone BCL6 Degraders

Benjamin R. Bellenie, Kwai-Ming J. Cheung, Ana Varela et al. · Journal of Medicinal Chemistry · 2020 · 72 citations · Full text

Carboxylesterase Notum Is a Druggable Target to Modulate Wnt Signaling

Elliott D. Bayle, Fredrik Svensson, Benjamin N. Atkinson et al. · Journal of Medicinal Chemistry · 2021 · 48 citations · Full text

High Proliferation Rate and a Compromised Spindle Assembly Checkpoint Confers Sensitivity to the MPS1 Inhibitor BOS172722 in Triple-Negative Breast Cancers

Simon Anderhub, Grace Wing-Yan Mak, Mark D. Gurden et al. · Molecular Cancer Therapeutics · 2019 · 37 citations

Introduction of a Methyl Group Curbs Metabolism of Pyrido[3,4-<i>d</i>]pyrimidine Monopolar Spindle 1 (MPS1) Inhibitors and Enables the Discovery of the Phase 1 Clinical Candidate <i>N</i>²-(2-Ethoxy-4-(4-methyl-4<i>H</i>-1,2,4-triazol-3-yl)phenyl)-6-methyl-<i>N</i>⁸-neopentylpyrido[3,4-<i>d</i>]pyrimidine-2,8-diamine (BOS172722)

Hannah L. Woodward, Paolo Innocenti, Kwai-Ming J. Cheung et al. · Journal of Medicinal Chemistry · 2018 · 33 citations · Full text