Grace Wing-Yan Mak - Concepedia

Author

Grace Wing-Yan Mak

Cancer Research UK ORCID

Also Known As

G W Y Mak, G. Mak, Grace Mak, Grace W Y Mak, Grace W. Mak, Grace W. Y. Mak, Grace W.Y. Mak, Grace Wing-Yan Mak

Publications

439

Citations

H-Index

Concepts

All Affiliations

Cancer Research UK Institute of Cancer Research Breast Cancer Now Chinese University of Hong Kong University of Hong Kong

About

Grace Wing-Yan Mak is an author at Cancer Research UK specializing in medicine, cancer research, and medicinal chemistry.

Top Concepts

#	Concept	H-Index	Publications	Citations
1	Medicine	4	4	234
2	Natural Sciences	2	2	111
3	Biochemistry	2	2	111
4	Cell Biology	2	2	123
5	Biomolecular Engineering	1	1	79

Grace Wing-Yan Mak

Publications

428

Citations

H-Index

Page 1

	Year	Citations
Overexpression of a Novel Activator of PAK4, the CDK5 Kinase–Associated Protein CDK5RAP3, Promotes Hepatocellular Carcinoma Metastasis Grace Wing-Yan Mak, Mandy Man-Lok Chan, Veronica Yee-Law Leong, Cancer Research Tumor BiologyHcc SpecimensHepatologyHcc Cell LinesMedicine	2011	90
Structure-Based Design of Orally Bioavailable 1<i>H</i>-Pyrrolo[3,2-<i>c</i>]pyridine Inhibitors of Mitotic Kinase Monopolar Spindle 1 (MPS1) Sébastien Naud, Isaac M. Westwood, Amir Faisal, Journal of Medicinal Chemistry Pharmaceutical ScienceMolecular BiologyMps1 InhibitionPharmaceutical ChemistrySelective Mps1 Inhibitors	2013	79
High Proliferation Rate and a Compromised Spindle Assembly Checkpoint Confers Sensitivity to the MPS1 Inhibitor BOS172722 in Triple-Negative Breast Cancers Simon Anderhub, Grace Wing-Yan Mak, Mark D. Gurden, Molecular Cancer Therapeutics	2019	37
CDK5RAP3 Is a Novel Repressor of p14ARF in Hepatocellular Carcinoma Cells Grace Wing-Yan Mak, Wai-Lung Lai, Yuan Zhou, PLoS ONE	2012	34
The LIM-only protein FHL2 regulates interleukin-6 expression through p38 MAPK mediated NF-κB pathway in muscle cells Chi Hang Wong, Grace Wing-Yan Mak, Man-Shan Li, Cytokine InflammationCytokineMuscle CellsSignal TransductionMolecular Physiology	2012	33
Introduction of a Methyl Group Curbs Metabolism of Pyrido[3,4-<i>d</i>]pyrimidine Monopolar Spindle 1 (MPS1) Inhibitors and Enables the Discovery of the Phase 1 Clinical Candidate <i>N</i><sup>2</sup>-(2-Ethoxy-4-(4-methyl-4<i>H</i>-1,2,4-triazol-3-yl)phenyl)-6-methyl-<i>N</i><sup>8</sup>-neopentylpyrido[3,4-<i>d</i>]pyrimidine-2,8-diamine (BOS172722) Hannah L. Woodward, Paolo Innocenti, Kwai-Ming J. Cheung, Journal of Medicinal Chemistry	2018	33
Rapid Discovery of Pyrido[3,4-<i>d</i>]pyrimidine Inhibitors of Monopolar Spindle Kinase 1 (MPS1) Using a Structure-Based Hybridization Approach Paolo Innocenti, Hannah L. Woodward, Savade Solanki, Journal of Medicinal Chemistry Molecular BiologyMps1 InhibitionTumor BiologyMedicinal ChemistryAnti-cancer Agent	2016	32
Naturally Occurring Mutations in the <i>MPS1</i> Gene Predispose Cells to Kinase Inhibitor Drug Resistance Mark D. Gurden, Isaac M. Westwood, Amir Faisal, Cancer Research	2015	31
Characterisation of CCT271850, a selective, oral and potent MPS1 inhibitor, used to directly measure in vivo MPS1 inhibition vs therapeutic efficacy Amir Faisal, Grace Wing-Yan Mak, Mark D. Gurden, British Journal of Cancer	2017	26
Quizartinib-resistant FLT3-ITD acute myeloid leukemia cells are sensitive to the FLT3-Aurora kinase inhibitor CCT241736 Andrew S. Moore, Amir Faisal, Grace Wing-Yan Mak, Blood Advances	2020	23

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