John Yonchuk

Monoacidic Inhibitors of the Kelch-like ECH-Associated Protein 1: Nuclear Factor Erythroid 2-Related Factor 2 (KEAP1:NRF2) Protein–Protein Interaction with High Cell Potency Identified by Fragment-Based Discovery

Thomas G. Davies, William E. Wixted, Joseph E. Coyle et al. · Journal of Medicinal Chemistry · 2016 · 295 citations · Full text

Molecular Biology, Chemical Biology, Redox Biology +19

Danirixin: A Reversible and Selective Antagonist of the CXC Chemokine Receptor 2

Jakob Busch‐Petersen, Donald C. Carpenter, Miriam Burman et al. · Journal of Pharmacology and Experimental Therapeutics · 2017 · 44 citations · Full text

Chemokine Biology, Immune Regulation, Immunology +20

Identification and characterisation of a salt form of Danirixin with reduced pharmacokinetic variability in patient populations

Jackie C. Bloomer, Claire Ambery, Bruce E. Miller et al. · European Journal of Pharmaceutics and Biopharmaceutics · 2017 · 21 citations

Salt Form, Pharmacokinetic Variability, Health Sciences +9

Characterization of the Potent, Selective Nrf2 Activator, 3-(Pyridin-3-Ylsulfonyl)-5-(Trifluoromethyl)-2H-Chromen-2-One, in Cellular and In Vivo Models of Pulmonary Oxidative Stress

John Yonchuk, Joseph P. Foley, Brian Bolognese et al. · Journal of Pharmacology and Experimental Therapeutics · 2017 · 20 citations · Full text