Amanda L. Lapworth

The BCKDH Kinase and Phosphatase Integrate BCAA and Lipid Metabolism via Regulation of ATP-Citrate Lyase

Phillip J. White, Robert W. McGarrah, Paul A. Grimsrud et al. · Cell Metabolism · 2018 · 352 citations · Full text

Life Sciences, Biochemistry, Enzymology +10

Branched-chain amino acid restriction in Zucker-fatty rats improves muscle insulin sensitivity by enhancing efficiency of fatty acid oxidation and acyl-glycine export

Phillip J. White, Amanda L. Lapworth, Jie An et al. · Molecular Metabolism · 2016 · 271 citations · Full text

Life Sciences, Nutritional Sciences, Physiology +17

Brain Insulin Lowers Circulating BCAA Levels by Inducing Hepatic BCAA Catabolism

Andrew C. Shin, Nika Filatova, Linus A. Grundell et al. · Cell Metabolism · 2014 · 149 citations · Full text

Life Sciences, Endocrinology, Neuroscience +10

Discovery of (<i>S</i>)-6-(3-Cyclopentyl-2-(4-(trifluoromethyl)-1<i>H</i>-imidazol-1-yl)propanamido)nicotinic Acid as a Hepatoselective Glucokinase Activator Clinical Candidate for Treating Type 2 Diabetes Mellitus

Jeffrey A. Pfefferkorn, Angel Guzmán-Pérez, John Litchfield et al. · Journal of Medicinal Chemistry · 2011 · 115 citations · Full text

Life Sciences, Biochemistry, Pharmacology +14

Muscle-Liver Trafficking of BCAA-Derived Nitrogen Underlies Obesity-Related Glycine Depletion

Phillip J. White, Amanda L. Lapworth, Robert W. McGarrah et al. · Cell Reports · 2020 · 78 citations · Full text

Life Sciences, Biochemistry, Physiology +17