Robert Hughes

NAD ⁺ cleavage activity by animal and plant TIR domains in cell death pathways

S. Horsefield, Hayden Burdett, Xiaoxiao Zhang et al. · Science · 2019 · 519 citations · Full text

Life Sciences, Cell Biology, Molecular Biology +17

A Chemical, Genetic, and Structural Analysis of the Nuclear Bile Acid Receptor FXR

Michael Downes, Mark A. Verdecia, Anthony J. Roecker et al. · Molecular Cell · 2003 · 386 citations · Full text

Life Sciences, Biochemistry, Genetics +13

SARM1 is a metabolic sensor activated by an increased NMN/NAD+ ratio to trigger axon degeneration

Matthew D. Figley, Weixi Gu, Jeffrey D. Nanson et al. · Neuron · 2021 · 338 citations · Full text

Life Sciences, Molecular Biology, Neuroscience +15

RORγt inhibition selectively targets IL-17 producing iNKT and γδ-T cells enriched in Spondyloarthritis patients

Koen Venken, Peggy Jacques, Céline Mortier et al. · Nature Communications · 2018 · 310 citations · Full text

Life Sciences, Immunology, Pathobiology +17

Small Molecule SARM1 Inhibitors Recapitulate the SARM1−/− Phenotype and Allow Recovery of a Metastable Pool of Axons Fated to Degenerate

Robert Hughes, Todd Bosanac, Xianrong Mao et al. · Cell Reports · 2021 · 191 citations · Full text

Life Sciences, Neurobiology, Neuroscience +17