Christine Gaydos

Beyond Rapalog Therapy: Preclinical Pharmacology and Antitumor Activity of WYE-125132, an ATP-Competitive and Specific Inhibitor of mTORC1 and mTORC2

Ker Yu, Celine Shi, Lourdes Toral‐Barza et al. · Cancer Research · 2010 · 208 citations · Full text

Medicine, Oncology, Pharmacology +14

PWT-458, a novel pegylated-17-hydroxywortmannin, inhibits phosphatidylinositol 3-kinase signaling and suppresses growth of solid tumors

Ker Yu, Judy Lucas, Tianmin Zhu et al. · Cancer Biology & Therapy · 2005 · 65 citations · Full text

Medicine, Oncology, Pharmacology +15

Hybrid Inhibitors of Phosphatidylinositol 3-Kinase (PI3K) and the Mammalian Target of Rapamycin (mTOR): Design, Synthesis, and Superior Antitumor Activity of Novel Wortmannin−Rapamycin Conjugates

Semiramis Ayral‐Kaloustian, Jianxin Gu, Judy Lucas et al. · Journal of Medicinal Chemistry · 2009 · 47 citations

Pharmacy, Medicinal Chemistry, Pharmacology +15

Synthesis and Structure–Activity Relationships of Ring-Opened 17-Hydroxywortmannins: Potent Phosphoinositide 3-Kinase Inhibitors with Improved Properties and Anticancer Efficacy

Arie Zask, Joshua A. Kaplan, Lourdes Toral‐Barza et al. · Journal of Medicinal Chemistry · 2008 · 34 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +14