Aberrant cleavage of TDP-43 enhances aggregation and cellular toxicity

Yong‐Jie Zhang, Ya-Fei Xu, Casey Cook, +14

Proceedings of the National Academy of Sciences

ApoptosisCell DeathMolecular BiologyToxicological MechanismAberrant Cleavage +16

Wild-Type Human TDP-43 Expression Causes TDP-43 Phosphorylation, Mitochondrial Aggregation, Motor Deficits, and Early Mortality in Transgenic Mice

Ya-Fei Xu, Tania F. Gendron, Yong‐Jie Zhang, +13

Journal of Neuroscience

Poly(GR) impairs protein translation and stress granule dynamics in C9orf72-associated frontotemporal dementia and amyotrophic lateral sclerosis

Yong‐Jie Zhang, Tania F. Gendron, Mark Ebbert, +20

Nature Medicine

Amyotrophic Lateral SclerosisAlzheimer's DiseaseDementiaProtein TranslationStress Granule Dynamics +7

C9ORF72 poly(GA) aggregates sequester and impair HR23 and nucleocytoplasmic transport proteins

Yong‐Jie Zhang, Tania F. Gendron, Jonathan C. Grima, +32

Nature Neuroscience

Protein FunctionSignal TransductionNucleocytoplasmic Transport ProteinsMedicineNatural Sciences +9

Poly(GP) proteins are a useful pharmacodynamic marker for <i>C9ORF72</i> -associated amyotrophic lateral sclerosis

Tania F. Gendron, Jeannie Chew, Jeannette N. Stankowski, +75

Science Translational Medicine

Heterochromatin anomalies and double-stranded RNA accumulation underlie <i>C9orf72</i> poly(PR) toxicity

Yong‐Jie Zhang, Lin Guo, Patrick Gonzales, +32

Science

<i>C9orf72</i> poly(GR) aggregation induces TDP-43 proteinopathy

Casey Cook, Yanwei Wu, Hana M. Odeh, +19

Science Translational Medicine

An acetylation–phosphorylation switch that regulates tau aggregation propensity and function

Yari Carlomagno, Dah-eun Chloe Chung, Mei Yue, +8

Journal of Biological Chemistry

Protein FunctionSignal TransductionSignaling PathwayMolecular RegulationNatural Sciences +9

Microglial lysosome dysfunction contributes to white matter pathology and TDP-43 proteinopathy in GRN-associated FTD

Yanwei Wu, Wei Shao, Tiffany W. Todd, +11

Cell Reports

Two FTD-ALS genes converge on the endosomal pathway to induce TDP-43 pathology and degeneration

Wei Shao, Tiffany W. Todd, Yanwei Wu, +20

Science