Cornelis K. van der Ent

Functional Repair of CFTR by CRISPR/Cas9 in Intestinal Stem Cell Organoids of Cystic Fibrosis Patients

Gerald Schwank, Bon‐Kyoung Koo, Valentina Sasselli et al. · Cell stem cell · 2013 · 1.4K citations · Full text

Life Sciences, Genetics, Molecular Biology +16

Long‐term expanding human airway organoids for disease modeling

Norman Sachs, Angelos Papaspyropoulos, Domenique D. Zomer-van Ommen et al. · The EMBO Journal · 2019 · 1.1K citations · Full text

Medicine, Pediatrics, Human Anatomy +16

A functional CFTR assay using primary cystic fibrosis intestinal organoids

Johanna F. Dekkers, Caroline L. Wiegerinck, Hugo R. de Jonge et al. · Nature Medicine · 2013 · 997 citations

Medicine, Cell Biology, Pharmacology +8

Tezacaftor–Ivacaftor in Patients with Cystic Fibrosis Homozygous for Phe508del

Jennifer L. Taylor‐Cousar, À. Munck, Edward F. McKone et al. · New England Journal of Medicine · 2017 · 778 citations · Full text

Medicine, Pharmacology, Pharmacotherapy +10

Characterizing responses to CFTR-modulating drugs using rectal organoids derived from subjects with cystic fibrosis

Johanna F. Dekkers, Gitte Berkers, Evelien Kruisselbrink et al. · Science Translational Medicine · 2016 · 549 citations

Medicine, Pharmacology, Clinical Pharmacology +8