Joseph Nacson

The BRCA1-Δ11q Alternative Splice Isoform Bypasses Germline Mutations and Promotes Therapeutic Resistance to PARP Inhibition and Cisplatin

Yifan Wang, Andrea J. Bernhardy, Cristina Cruz et al. · Cancer Research · 2016 · 271 citations · Full text

Medicine, Genetics, Oncology +16

BRCA1 Mutation-Specific Responses to 53BP1 Loss-Induced Homologous Recombination and PARP Inhibitor Resistance

Joseph Nacson, John J. Krais, Andrea J. Bernhardy et al. · Cell Reports · 2018 · 98 citations · Full text

Life Sciences, Genetics, Molecular Biology +13

BRCA1 intronic Alu elements drive gene rearrangements and PARP inhibitor resistance

Yifan Wang, Andrea J. Bernhardy, Joseph Nacson et al. · Nature Communications · 2019 · 63 citations · Full text

Life Sciences, Genetics, Oncology +16

BRCA1 Mutational Complementation Induces Synthetic Viability

Joseph Nacson, Daniela Di Marcantonio, Yifan Wang et al. · Molecular Cell · 2020 · 60 citations · Full text

Life Sciences, Genetics, Molecular Biology +5

<i>TET2</i> and <i>DNMT3A</i> Mutations Exert Divergent Effects on DNA Repair and Sensitivity of Leukemia Cells to PARP Inhibitors

Silvia Maifrede, Bac Viet Le, Margaret Nieborowska-Skorska et al. · Cancer Research · 2021 · 51 citations · Full text

Life Sciences, Molecular Biology, Oncology +17