Replication gaps are a key determinant of PARP inhibitor synthetic lethality with BRCA deficiency

Ke Cong, Min Peng, Arne Nedergaard Kousholt, +13

Molecular Cell

Genome InstabilityNatural SciencesKey DeterminantMolecular BiologyDna Replication +6

Methylation of all BRCA1 copies predicts response to the PARP inhibitor rucaparib in ovarian carcinoma

Olga Kondrashova, Monique Topp, Ksenija Nesic, +20

Nature Communications

The BRCA1-Δ11q Alternative Splice Isoform Bypasses Germline Mutations and Promotes Therapeutic Resistance to PARP Inhibition and Cisplatin

Yifan Wang, Andrea J. Bernhardy, Cristina Cruz, +24

Cancer Research

RING domain–deficient BRCA1 promotes PARP inhibitor and platinum resistance

Yifan Wang, John J. Krais, Andrea J. Bernhardy, +8

Journal of Clinical Investigation

BRCA1 Mutation-Specific Responses to 53BP1 Loss-Induced Homologous Recombination and PARP Inhibitor Resistance

Joseph Nacson, John J. Krais, Andrea J. Bernhardy, +17

Cell Reports

Targeting single-walled carbon nanotubes for the treatment of breast cancer using photothermal therapy

Luís F. Neves, John J. Krais, Brent D. Van Rite, +3

Nanotechnology

NanomedicineEngineeringCarbon-based MaterialNanomaterialsNanobiotechnology +13

ATF3 coordinates serine and nucleotide metabolism to drive cell cycle progression in acute myeloid leukemia

Daniela Di Marcantonio, Esteban Martı́nez, Joice Kanefsky, +13

Molecular Cell

Hematological MalignancyChromatinCell Cycle ProgressionCell DivisionMixed-phenotype Acute Leukemia +8

RNF168-mediated localization of BARD1 recruits the BRCA1-PALB2 complex to DNA damage

John J. Krais, Yifan Wang, Pooja Patel, +3

Nature Communications

BRCA1 intronic Alu elements drive gene rearrangements and PARP inhibitor resistance

Yifan Wang, Andrea J. Bernhardy, Joseph Nacson, +11

Nature Communications

Discovery of a small-molecule inhibitor that traps Polθ on DNA and synergizes with PARP inhibitors

William Fried, Mrityunjay Tyagi, Leonid Minakhin, +20

Nature Communications