John J. Krais

Replication gaps are a key determinant of PARP inhibitor synthetic lethality with BRCA deficiency

Ke Cong, Min Peng, Arne Nedergaard Kousholt et al. · Molecular Cell · 2021 · 322 citations · Full text

Life Sciences, Cancer Biology, Molecular Biology +17

Methylation of all BRCA1 copies predicts response to the PARP inhibitor rucaparib in ovarian carcinoma

Olga Kondrashova, Monique Topp, Ksenija Nesic et al. · Nature Communications · 2018 · 292 citations · Full text

Medicine, Molecular Genetics, Oncology +17

The BRCA1-Δ11q Alternative Splice Isoform Bypasses Germline Mutations and Promotes Therapeutic Resistance to PARP Inhibition and Cisplatin

Yifan Wang, Andrea J. Bernhardy, Cristina Cruz et al. · Cancer Research · 2016 · 271 citations · Full text

Medicine, Genetics, Oncology +16

RING domain–deficient BRCA1 promotes PARP inhibitor and platinum resistance

Yifan Wang, John J. Krais, Andrea J. Bernhardy et al. · Journal of Clinical Investigation · 2016 · 109 citations · Full text

Medicine, Molecular Biology, Oncology +15

BRCA1 Mutation-Specific Responses to 53BP1 Loss-Induced Homologous Recombination and PARP Inhibitor Resistance

Joseph Nacson, John J. Krais, Andrea J. Bernhardy et al. · Cell Reports · 2018 · 98 citations · Full text

Life Sciences, Genetics, Molecular Biology +13