Ke Cong

Replication gaps are a key determinant of PARP inhibitor synthetic lethality with BRCA deficiency

Ke Cong, Min Peng, Arne Nedergaard Kousholt et al. · Molecular Cell · 2021 · 298 citations · Full text

Genome Instability, Natural Sciences, Key Determinant +8

Inhibition of the translesion synthesis polymerase REV1 exploits replication gaps as a cancer vulnerability

Sumeet U. Nayak, Jennifer A. Calvo, Ke Cong et al. · Science Advances · 2020 · 117 citations · Full text

Chromatin, Genome Instability, Tls Factor Rev1 +15

Loss of nuclear DNA ligase III reverts PARP inhibitor resistance in BRCA1/53BP1 double-deficient cells by exposing ssDNA gaps

Mariana Paes Dias, Vivek Tripathi, Ingrid van der Heijden et al. · Molecular Cell · 2021 · 86 citations · Full text

Genome Instability, Genetics, Parp Inhibitor Resistance +8

Opposing Roles of FANCJ and HLTF Protect Forks and Restrain Replication during Stress

Min Peng, Ke Cong, Nicholas J. Panzarino et al. · Cell Reports · 2018 · 73 citations · Full text

PARPi synthetic lethality derives from replication-associated single-stranded DNA gaps

Ke Cong, Arne Nedergaard Kousholt, Min Peng et al. · 2019 · 21 citations · Full text

Chromatin, Genome Instability, Dna Damage +11