Humberto Arzeno

Design and Synthesis of 4-Azaindoles as Inhibitors of p38 MAP Kinase

Alejandra Trejo, Humberto Arzeno, Michelle F. Browner et al. · Journal of Medicinal Chemistry · 2003 · 94 citations · Full text

Combinatorial Chemistry, Bioorganic Chemistry, P38 Map Kinase +17

Discovery of 6-(2,4-Difluorophenoxy)-2-[3-hydroxy-1-(2-hydroxyethyl)propylamino]-8-methyl-8<i>H</i>-pyrido[2,3-<i>d</i>]pyrimidin-7-one (Pamapimod) and 6-(2,4-Difluorophenoxy)-8-methyl-2-(tetrahydro-2<i>H</i>-pyran-4-ylamino)pyrido[2,3-<i>d</i>]pyrimidin-7(8<i>H</i>)-one (R1487) as Orally Bioavailable and Highly Selective Inhibitors of p38α Mitogen-Activated Protein Kinase

David Goldstein, Michael Soth, Tobias Gabriel et al. · Journal of Medicinal Chemistry · 2011 · 74 citations · Full text

Pharmacotherapy, New Series, System Pharmacology +21

3-Amino-pyrazolo[3,4-d]pyrimidines as p38α kinase inhibitors: Design and development to a highly selective lead

Michael Soth, Sarah C. Abbot, Allassan Abubakari et al. · Bioorganic & Medicinal Chemistry Letters · 2011 · 27 citations · Full text

Molecular Pharmacology, Medicinal Chemistry, Drug Target +11

Development of amino-pyrimidine inhibitors of c-Jun N-terminal kinase (JNK): Kinase profiling guided optimization of a 1,2,3-benzotriazole lead

Wylie S. Palmer, Muzaffar Alam, Humberto Arzeno et al. · Bioorganic & Medicinal Chemistry Letters · 2012 · 25 citations · Full text

Amino-pyrimidine Inhibitors, Medicinal Chemistry, Pharmaceutical Chemistry +12

Design and synthesis of orally active inhibitors of TNF synthesis as anti-rheumatoid arthritis drugs

Jian Jeffrey Chen, Nolan Dewdney, Xiaohong Lin et al. · Bioorganic & Medicinal Chemistry Letters · 2003 · 19 citations

Tnf Synthesis, Rheumatology, Rheumatoid Disorder +10