Nolan Dewdney

Structure-Based Drug Design of RN486, a Potent and Selective Bruton’s Tyrosine Kinase (BTK) Inhibitor, for the Treatment of Rheumatoid Arthritis

Yan Lou, Xiaochun Han, A. Kuglstatter et al. · Journal of Medicinal Chemistry · 2014 · 106 citations

Pharmaceutical Science, Tyrosine Kinase, Immunology +18

Discovery of 6-(2,4-Difluorophenoxy)-2-[3-hydroxy-1-(2-hydroxyethyl)propylamino]-8-methyl-8<i>H</i>-pyrido[2,3-<i>d</i>]pyrimidin-7-one (Pamapimod) and 6-(2,4-Difluorophenoxy)-8-methyl-2-(tetrahydro-2<i>H</i>-pyran-4-ylamino)pyrido[2,3-<i>d</i>]pyrimidin-7(8<i>H</i>)-one (R1487) as Orally Bioavailable and Highly Selective Inhibitors of p38α Mitogen-Activated Protein Kinase

David Goldstein, Michael Soth, Tobias Gabriel et al. · Journal of Medicinal Chemistry · 2011 · 74 citations · Full text

Pharmacotherapy, New Series, System Pharmacology +21

Acyloin formation by benzoylformate decarboxylase from Pseudomonas putida

Richard Wilcocks, O. P. Ward, Scott Collins et al. · Applied and Environmental Microbiology · 1992 · 72 citations · Full text

Biosynthesis, Bioorganic Chemistry, Benzyl Alcohol +14

Novel indolactam-based inhibitors of matrix metalloproteinases

Arlindo L. Castelhano, Roland Billedeau, Nolan Dewdney et al. · Bioorganic & Medicinal Chemistry Letters · 1995 · 53 citations

Medicinal Chemistry, Novel Indolactam-based Inhibitors, Medicine +6

Design, synthesis, activity, and structure of a novel class of matrix metalloproteinase inhibitors containing a heterocyclic P2′-P3′ amide bond isostere

Jian Jeffrey Chen, Yiping Zhang, Scott M. Hammond et al. · Bioorganic & Medicinal Chemistry Letters · 1996 · 37 citations

Medicinal Chemistry, Biochemistry, Medicine +9