Muzaffar Alam

3-Amido Pyrrolopyrazine JAK Kinase Inhibitors: Development of a JAK3 vs JAK1 Selective Inhibitor and Evaluation in Cellular and in Vivo Models

Michael Soth, Johannes C. Hermann, Calvin Yee et al. · Journal of Medicinal Chemistry · 2012 · 66 citations · Full text

Drug Target, Janus Kinases, Immunology +21

Identification and SAR of novel diaminopyrimidines. Part 1: The discovery of RO-4, a dual P2X3/P2X2/3 antagonist for the treatment of pain

David S. Carter, Muzaffar Alam, Haiying Cai et al. · Bioorganic & Medicinal Chemistry Letters · 2009 · 62 citations · Full text

Medicinal Chemistry, Biochemistry, Medicine +10

Identification and SAR of novel diaminopyrimidines. Part 2: The discovery of RO-51, a potent and selective, dual P2X3/P2X2/3 antagonist for the treatment of pain

Alam Jahangir, Muzaffar Alam, David S. Carter et al. · Bioorganic & Medicinal Chemistry Letters · 2009 · 49 citations · Full text

Medicinal Chemistry, Biochemistry, Pain Medicine +10

Development of amino-pyrimidine inhibitors of c-Jun N-terminal kinase (JNK): Kinase profiling guided optimization of a 1,2,3-benzotriazole lead

Wylie S. Palmer, Muzaffar Alam, Humberto Arzeno et al. · Bioorganic & Medicinal Chemistry Letters · 2012 · 25 citations · Full text

Amino-pyrimidine Inhibitors, Medicinal Chemistry, Pharmaceutical Chemistry +12