Disruptions of Topological Chromatin Domains Cause Pathogenic Rewiring of Gene-Enhancer Interactions

Darío G. Lupiáñez, Katerina Kraft, Verena Heinrich, +19

Cell

ChromatinChromatin StructureChromatin RemodelingNatural SciencesEpigenetic Change +9

Formation of new chromatin domains determines pathogenicity of genomic duplications

Martin Franke, Daniel M. Ibrahim, Guillaume Andrey, +20

Nature

ChromatinGenome InstabilityChromatin StructureChromatin RemodelingNatural Sciences +10

ecDNA hubs drive cooperative intermolecular oncogene expression

King L. Hung, Kathryn E. Yost, Liangqi Xie, +31

Nature

ChromatinEcdna HubsMolecular ResearchNatural SciencesDna Replication +4

Polymer physics predicts the effects of structural variants on chromatin architecture

Simona Bianco, Darío G. Lupiáñez, Andrea M. Chiariello, +9

Nature Genetics

ChromatinStructural VariantsChromatin StructureChromatin RemodelingChromatin Architecture +10

Deletions, Inversions, Duplications: Engineering of Structural Variants using CRISPR/Cas in Mice

Katerina Kraft, Sinje Geuer, Anja J. Will, +12

Cell Reports

Dynamic 3D chromatin architecture contributes to enhancer specificity and limb morphogenesis

Bjørt K. Kragesteen, Malte Spielmann, Christina Paliou, +21

Nature Genetics

ChromatinDevelopmental BiologyLimb MorphogenesisChromatin RemodelingChromatin Architecture +8

Identifying cis Elements for Spatiotemporal Control of Mammalian DNA Replication

Jiao Sima, Abhijit Chakraborty, Vishnu Dileep, +18

Cell

ChromatinGenome InstabilityDna SequencingNatural SciencesGenetics +7

Xist ribonucleoproteins promote female sex-biased autoimmunity

Diana R. Dou, Yanding Zhao, Julia A. Belk, +20

Cell

Xist Rnp ComplexesImmunogeneticsAutoimmune DiseaseXist RibonucleoproteinsAutoantibody Production +13

Serial genomic inversions induce tissue-specific architectural stripes, gene misexpression and congenital malformations

Katerina Kraft, Andreas Magg, Verena Heinrich, +11

Nature Cell Biology

Tissue-specific Architectural StripesDevelopmental BiologyGenetic DisorderGeneticsGenomic Mechanism +7

Polycomb-mediated genome architecture enables long-range spreading of H3K27 methylation

Katerina Kraft, Kathryn E. Yost, Sedona E. Murphy, +9

Proceedings of the National Academy of Sciences

Epigenetic ChangeGeneticsDna MethylationMolecular BiologyEpigenetics +17