Mukesh Mahajan

RIP1 Kinase Drives Macrophage-Mediated Adaptive Immune Tolerance in Pancreatic Cancer

Wei Wang, Jill M. Marinis, Allison M. Beal et al. · Cancer Cell · 2018 · 250 citations · Full text

Life Sciences, Immunology, Oncology +16

The Identification and Pharmacological Characterization of 6-( <i>tert</i> -Butylsulfonyl)- <i>N</i> -(5-fluoro-1 <i>H</i> -indazol-3-yl)quinolin-4-amine (GSK583), a Highly Potent and Selective Inhibitor of RIP2 Kinase

Pamela A. Haile, Bartholomew J. Votta, Robert W. Marquis et al. · Journal of Medicinal Chemistry · 2016 · 124 citations · Full text

Life Sciences, Medicinal Chemistry, Pharmacology +17

Identification of a RIP1 Kinase Inhibitor Clinical Candidate (GSK3145095) for the Treatment of Pancreatic Cancer

Philip A. Harris, Jill M. Marinis, John D. Lich et al. · ACS Medicinal Chemistry Letters · 2019 · 85 citations · Full text

Medicine, Medicinal Chemistry, Oncology +12

NMR identification of a conserved Drp1 cardiolipin-binding motif essential for stress-induced mitochondrial fission

Mukesh Mahajan, Nikhil Bharambe, Yutong Shang et al. · Proceedings of the National Academy of Sciences · 2021 · 76 citations · Full text

Life Sciences, Biochemistry, Cell Biology +17

Discovery and Lead-Optimization of 4,5-Dihydropyrazoles as Mono-Kinase Selective, Orally Bioavailable and Efficacious Inhibitors of Receptor Interacting Protein 1 (RIP1) Kinase

Philip A. Harris, Nicolas Faucher, Nicolas George et al. · Journal of Medicinal Chemistry · 2019 · 69 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +14