William G. Bonnette

A DNA Hypomethylation Signature Predicts Antitumor Activity of LSD1 Inhibitors in SCLC

Helai P. Mohammad, Kimberly N. Smitheman, Chandrashekhar D. Kamat et al. · Cancer Cell · 2015 · 512 citations · Full text

Medicine, Molecular Biology, Oncology +12

Structure-Based Design of a Novel SMYD3 Inhibitor that Bridges the SAM-and MEKK2-Binding Pockets

Glenn S. Van Aller, Alan P. Graves, P.A. Elkins et al. · Structure · 2016 · 62 citations · Full text

Pharmacy, Biochemistry, Medicinal Chemistry +14

Long-Range Inhibitor-Induced Conformational Regulation of Human IRE1α Endoribonuclease Activity

N.O. Concha, Angela Smallwood, William G. Bonnette et al. · Molecular Pharmacology · 2015 · 54 citations

Life Sciences, Biochemistry, Molecular Biology +16

A High-Throughput Dose-Response Cellular Thermal Shift Assay for Rapid Screening of Drug Target Engagement in Living Cells, Exemplified Using SMYD3 and IDO1

Dean E. McNulty, William G. Bonnette, Hongwei Qi et al. · SLAS DISCOVERY · 2017 · 51 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +15

Fragment-Guided Discovery of Pyrazole Carboxylic Acid Inhibitors of the Kelch-like ECH-Associated Protein 1: Nuclear Factor Erythroid 2 Related Factor 2 (KEAP1:NRF2) Protein−Protein Interaction

David L. Norton, William G. Bonnette, James F. Callahan et al. · Journal of Medicinal Chemistry · 2021 · 32 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17