Discovery of GSK2126458, a Highly Potent Inhibitor of PI3K and the Mammalian Target of Rapamycin

Steven D. Knight, Nicholas D. Adams, Joelle L. Burgess, +28

ACS Medicinal Chemistry Letters

Highly Potent InhibitorTumor BiologyMammalian TargetSignaling PathwayCancer Cell Biology +14

Indole Naphthyridinones as Inhibitors of Bacterial Enoyl-ACP Reductases FabI and FabK

Mark A. Seefeld, William H. Miller, Kenneth A. Newlander, +17

Journal of Medicinal Chemistry

Bioorganic ChemistryChemical BiologyPharmaceutical ChemistryDrug ResistanceMedicinal Chemistry +18

Structure of the C-terminally truncated human ProMMP9, a gelatin-binding matrix metalloproteinase

P.A. Elkins, Yen Sen Ho, Ward W. Smith, +5

Acta Crystallographica Section D Biological Crystallography

A mechanism for toxin insertion into membranes is suggested by the crystal structure of the channel-forming domain of colicin E1

P.A. Elkins, Amy Bunker, William Cramer, +1

Structure

Microbial ToxinCrystal StructureMembrane FormationBiochemistryMedicine +7

Insights into Catalysis by a Knotted TrmD tRNA Methyltransferase

P.A. Elkins, Joseph Watts, Magdalena Zalacaín, +6

Journal of Molecular Biology

Natural SciencesBiocatalysisMolecular BiologyEnzyme Catalysis

CSAR 2014: A Benchmark Exercise Using Unpublished Data from Pharma

Heather A. Carlson, Richard D. Smith, Kelly L. Damm‐Ganamet, +10

Journal of Chemical Information and Modeling

Discovery of a Potent Class of PI3Kα Inhibitors with Unique Binding Mode via Encoded Library Technology (ELT)

Hongfang Yang, Patrícia Flores de Medeiros, Kaushik Raha, +18

ACS Medicinal Chemistry Letters

Molecular DockingDrug TargetBiochemistryStructural BioinformaticsMedicine +13

Potent, Selective and Orally Bioavailable Dihydropyrimidine Inhibitors of Rho Kinase (ROCK1) as Potential Therapeutic Agents for Cardiovascular Diseases

Clark A. Sehon, Gren Z. Wang, Andrew Q. Viet, +17

Journal of Medicinal Chemistry

Medicinal ChemistryPotential Therapeutic AgentsBiochemistryRho KinaseMedicine +13

Discovery of Aminofurazan-azabenzimidazoles as Inhibitors of Rho-Kinase with High Kinase Selectivity and Antihypertensive Activity

Robert A. Stavenger, Haifeng Cui, Sarah E. Dowdell, +30

Journal of Medicinal Chemistry

Drug TargetBioorganic ChemistryPharmacotherapyChemical BiologyPharmaceutical Chemistry +16

Structure-Based Design of a Novel SMYD3 Inhibitor that Bridges the SAM-and MEKK2-Binding Pockets

Glenn S. Van Aller, Alan P. Graves, P.A. Elkins, +9

Structure

Chemical BiologyNovel Smyd3 InhibitorMedicinal ChemistryProtein AssemblyBiochemistry +11