Radoslav Aleksandrov

Genome-wide and high-density CRISPR-Cas9 screens identify point mutations in PARP1 causing PARP inhibitor resistance

Stephen J. Pettitt, Dragomir B. Krastev, Inger Brandsma et al. · Nature Communications · 2018 · 435 citations · Full text

Protein Dynamics in Complex DNA Lesions

Radoslav Aleksandrov, Anton Dotchev, Ina Poser et al. · Molecular Cell · 2018 · 170 citations

Chromatin, Genome Instability, Protein Folding +7

PARP1-DNA co-condensation drives DNA repair site assembly to prevent disjunction of broken DNA ends

Nagaraja Chappidi, Thomas Quail, Simon Doll et al. · Cell · 2024 · 119 citations · Full text

Chromatin, Genome Instability, Dsb Sites +14

PARP1 roles in DNA repair and DNA replication: The basi(c)s of PARP inhibitor efficacy and resistance

Petar-Bogomil Kanev, Aleksandar Atemin, Stoyno Stoynov et al. · Seminars in Oncology · 2023 · 58 citations · Full text

Genome Instability, Parp Inhibition, Natural Sciences +11

A unified mechanism for PARP inhibitor-induced PARP1 chromatin retention at DNA damage sites in living cells

Petar-Bogomil Kanev, Sylvia Varhoshkova, Irina Georgieva et al. · Cell Reports · 2024 · 29 citations · Full text