Senolytic CAR T cells reverse senescence-associated pathologies

Corina Amor, Judith Feucht, Josef Leibold, +15

Nature

T-regulatory CellImmunologyCellular SenescenceAutoimmunityImmunotherapy +3

Clonal dynamics of native haematopoiesis

Jianlong Sun, Azucena Ramos, Brad Chapman, +6

Nature

Cell DivisionHematologyBlood CellMorphogenesisCell Transplantation +4

Genome-wide detection of DNA double-stranded breaks induced by engineered nucleases

Richard L. Frock, Jiazhi Hu, Robin M. Meyers, +3

Nature Biotechnology

Spatial Organization of the Mouse Genome and Its Role in Recurrent Chromosomal Translocations

Yu Zhang, Rachel Patton McCord, Yu-Jui Ho, +6

Cell

ChromatinPattern FormationDevelopmental BiologyGeneticsRecurrent Chromosomal Translocations +7

Calibration of CAR activation potential directs alternative T cell fates and therapeutic potency

Judith Feucht, Jie Sun, Justin Eyquem, +7

Nature Medicine

Signal TransductionAdaptive Immune SystemT-regulatory CellImmunologyAutoimmunity +6

Genome-wide Translocation Sequencing Reveals Mechanisms of Chromosome Breaks and Rearrangements in B Cells

Roberto Chiarle, Yu Zhang, Richard L. Frock, +12

Cell

ChromatinGenome InstabilityGeneticsB CellsChromosome Biology +6

p53 Represses the Mevalonate Pathway to Mediate Tumor Suppression

Sung‐Hwan Moon, Chun‐Hao Huang, Shauna L Houlihan, +18

Cell

MedicineMevalonate PathwayTumor SuppressorCancer BiologyCell Biology +2

NK cell–mediated cytotoxicity contributes to tumor control by a cytostatic drug combination

Marcus Ruscetti, Josef Leibold, Matthew J. Bott, +17

Science

Senescence-Induced Vascular Remodeling Creates Therapeutic Vulnerabilities in Pancreas Cancer

Marcus Ruscetti, John P. Morris, Riccardo Mezzadra, +17

Cell

Pancreatic CancerPancreas CancerCellular SenescenceMedicineCell Biology +4

A gene–environment-induced epigenetic program initiates tumorigenesis

Direna Alonso‐Curbelo, Yu-Jui Ho, Cassandra Burdziak, +17

Nature

ChromatinChromatin StructureMedicineNatural SciencesMolecular Epigenetics +7