Senolytic CAR T cells reverse senescence-associated pathologies

Corina Amor, Judith Feucht, Josef Leibold, +15

Nature

T-regulatory CellImmunologyCellular SenescenceAutoimmunityImmunotherapy +3

Calibration of CAR activation potential directs alternative T cell fates and therapeutic potency

Judith Feucht, Jie Sun, Justin Eyquem, +7

Nature Medicine

Signal TransductionAdaptive Immune SystemT-regulatory CellImmunologyAutoimmunity +6

NK cell–mediated cytotoxicity contributes to tumor control by a cytostatic drug combination

Marcus Ruscetti, Josef Leibold, Matthew J. Bott, +17

Science

Senescence-Induced Vascular Remodeling Creates Therapeutic Vulnerabilities in Pancreas Cancer

Marcus Ruscetti, John P. Morris, Riccardo Mezzadra, +17

Cell

Pancreatic CancerPancreas CancerCellular SenescenceMedicineCell Biology +4

In vivo RNAi screening identifies a mechanism of sorafenib resistance in liver cancer

Ramona Rudalska, Daniel Dauch, Thomas Longerich, +18

Nature Medicine

Tumor BiologySystems BiologyEngineeringMedicineLiver Physiology +11

Quantitative self-assembly prediction yields targeted nanomedicines

Yosi Shamay, Janki Shah, Mehtap Işık, +18

Nature Materials

NanoparticlesNanomedicineEngineeringNanobiotechnologyMolecular Self-assembly +3

Induction of Oxidative Stress Through Inhibition of Thioredoxin Reductase 1 Is an Effective Therapeutic Approach for Hepatocellular Carcinoma

Derek Lee, Mingjing Xu, David Kung‐Chun Chiu, +13

Hepatology

The Oncogenic Action of NRF2 Depends on De-glycation by Fructosamine-3-Kinase

Viraj R. Sanghvi, Josef Leibold, Marco Mina, +13

Cell

Reductive StressSignal TransductionSignaling PathwayBiochemistryNrf2 Depends +7

Base editing sensor libraries for high-throughput engineering and functional analysis of cancer-associated single nucleotide variants

Francisco J. Sánchez‐Rivera, Bianca J. Diaz, Edward R. Kastenhuber, +18

Nature Biotechnology

High-throughput EngineeringFunctional GenomicsEngineeringGenome SurgeryBiomolecular Tool +11

Senescence induction dictates response to chemo- and immunotherapy in preclinical models of ovarian cancer

Stella Paffenholz, Camilla Salvagno, Yu-Jui Ho, +11

Proceedings of the National Academy of Sciences

ImmunologyImmunoeditingCancer BiologyTumor BiologyOvarian Aging +14