Alessandra Cappellini

The novel Akt inhibitor, perifosine, induces caspase-dependent apoptosis and downregulates P-glycoprotein expression in multidrug-resistant human T-acute leukemia cells by a JNK-dependent mechanism

Francesca Chiarini, Montse Solé, Sara Mongiorgi et al. · Leukemia · 2008 · 132 citations · Full text

Life Sciences, Oncology, Pharmacology +17

Proapoptotic activity and chemosensitizing effect of the novel Akt inhibitor perifosine in acute myelogenous leukemia cells

Verónica Papa, Pier Luigi Tazzari, Francesca Chiarini et al. · Leukemia · 2007 · 105 citations · Full text

Medicine, Oncology, Pharmacology +16

Diacylglycerol kinase-θ is localized in the speckle domains of the nucleus

Giovanna Tabellini, Roberta Bortul, Spartaco Santi et al. · Experimental Cell Research · 2003 · 98 citations · Full text

Life Sciences, Cell Biology, Molecular Biology +10

Constitutively active Akt1 protects HL60 leukemia cells from TRAIL-induced apoptosis through a mechanism involving NF-κB activation and cFLIPL up-regulation

Roberta Bortul, Pier Luigi Tazzari, Alessandra Cappellini et al. · Leukemia · 2003 · 93 citations

Life Sciences, Molecular Biology, Oncology +17

The Akt/Mammalian Target of Rapamycin Signal Transduction Pathway Is Activated in High-Risk Myelodysplastic Syndromes and Influences Cell Survival and Proliferation

Matilde Y. Follo, Sara Mongiorgi, Costanza Bosi et al. · Cancer Research · 2007 · 90 citations · Full text

Medicine, Oncology, Pharmacology +17