Resistance to dasatinib in Philadelphia-positive leukemia patients and the presence or the selection of mutations at residues 315 and 317 in the BCR-ABL kinase domain

Simona Soverini, Sabrina Colarossi, Alessandra Gnani, +16

Haematologica

EngineeringMixed-phenotype Acute LeukemiaPathologyTumor BiologyMyeloid Neoplasia +16

Life after ruxolitinib: Reasons for discontinuation, impact of disease phase, and outcomes in 218 patients with myelofibrosis

Francesca Palandri, Massimo Breccia, Massimiliano Bonifacio, +33

Cancer

Reduction of phosphoinositide-phospholipase C beta1 methylation predicts the responsiveness to azacitidine in high-risk MDS

Matilde Y. Follo, Carlo Finelli, Sara Mongiorgi, +10

Proceedings of the National Academy of Sciences

Hematological MalignancyMixed-phenotype Acute LeukemiaAcute Myeloid LeukemiaMds PatientsPharmacology +11

Frequent elevation of Akt kinase phosphorylation in blood marrow and peripheral blood mononuclear cells from high-risk myelodysplastic syndrome patients

Maria Nyåkern, Pier Luigi Tazzari, Carlo Finelli, +7

Leukemia

Hematological MalignancyBone Marrow FailureAkt Kinase PhosphorylationMalignant Blood DisorderImmunology +9

The Akt/Mammalian Target of Rapamycin Signal Transduction Pathway Is Activated in High-Risk Myelodysplastic Syndromes and Influences Cell Survival and Proliferation

Matilde Y. Follo, Sara Mongiorgi, Costanza Bosi, +8

Cancer Research

Baseline factors associated with response to ruxolitinib: an independent study on 408 patients with myelofibrosis

Francesca Palandri, Giuseppe A. Palumbo, Massimiliano Bonifacio, +34

Oncotarget

Phosphoinositide-Phospholipase C β1 Mono-Allelic Deletion Is Associated With Myelodysplastic Syndromes Evolution Into Acute Myeloid Leukemia

Matilde Y. Follo, Carlo Finelli, Cristina Clissa, +7

Journal of Clinical Oncology

Epidemiology, outcome, and risk factors for infectious complications in myelofibrosis patients receiving ruxolitinib: A multicenter study on 446 patients

Nicola Polverelli, Giuseppe A. Palumbo, Gianni Binotto, +29

Hematological Oncology

An increased expression of PI-PLCβ1 is associated with myeloid differentiation and a longer response to azacitidine in myelodysplastic syndromes

Lucio Cocco, Carlo Finelli, Sara Mongiorgi, +12

Journal of Leukocyte Biology

Real-time PCR as a tool for quantitative analysis of PI-PLCβ1 gene expression in myelodysplastic syndrome

Costanza Bosi, Carlo Finelli, Roberta Fiume, +5

International Journal of Molecular Medicine

Mixed-phenotype Acute LeukemiaGeneticsMolecular BiologyDisease Gene IdentificationReal-time Polymerase Chain Reaction +22