Concepedia

Proapoptotic activity and chemosensitizing effect of the novel Akt inhibitor perifosine in acute myelogenous leukemia cells

Verónica Papa, Pier Luigi Tazzari, Francesca Chiarini, Alessandra Cappellini, Francesca Ricci, Anna Maria Billi, Camilla Evangelisti, Emanuela Ottaviani, Giovanni Martinelli, Nicoletta Testoni,

Leukemia · 2007 · 105 citations · 39 references

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39

Perifosine, an oral bioactive novel alkylphospholipid, inhibits Akt and induces in vitro and in vivo cytotoxicity in human multiple myeloma cells

Teru Hideshima, Laurence Catley, Hiroshi Yasui et al. · Blood · 2006 · 421 citations · Full text

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The BAD protein integrates survival signaling by EGFR/MAPK and PI3K/Akt kinase pathways in PTEN-deficient tumor cells

Qing‐Bai She, David B. Solit, Qing Ye et al. · Cancer Cell · 2005 · 420 citations

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Perifosine, a novel alkylphospholipid, inhibits protein kinase B activation.

Sudhir B. Kondapaka, Sheo S. Singh, Girija Dasmahapatra et al. · PubMed · 2003 · 405 citations

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Rapamycin derivatives reduce mTORC2 signaling and inhibit AKT activation in AML

Zhihong Zeng, Dos D. Sarbassov, Ismael Samudio et al. · Blood · 2006 · 343 citations · Full text

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Phosphorylation of Ser-241 is essential for the activity of 3-phosphoinositide-dependent protein kinase-1: identification of five sites of phosphorylation in vivo

Antonio Casamayor, Nick Morrice, Dario R. Alessi · Biochemical Journal · 1999 · 340 citations · Full text

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