Concepedia

The novel Akt inhibitor, perifosine, induces caspase-dependent apoptosis and downregulates P-glycoprotein expression in multidrug-resistant human T-acute leukemia cells by a JNK-dependent mechanism

Francesca Chiarini, Montse Solé, Sara Mongiorgi, Alessandra Cappellini, Irina Mantovani, M.Y. Follo, James A. McCubrey, A M Martelli

Leukemia · 2008 · 132 citations · 30 references

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References

30

Perifosine, an oral bioactive novel alkylphospholipid, inhibits Akt and induces in vitro and in vivo cytotoxicity in human multiple myeloma cells

Teru Hideshima, Laurence Catley, Hiroshi Yasui et al. · Blood · 2006 · 421 citations · Full text

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Perifosine, a novel alkylphospholipid, inhibits protein kinase B activation.

Sudhir B. Kondapaka, Sheo S. Singh, Girija Dasmahapatra et al. · PubMed · 2003 · 405 citations

, , +17

P-Glycoprotein Protects Leukemia Cells Against Caspase-Dependent, but not Caspase-Independent, Cell Death

Ricky W. Johnstone, Erika Cretney, Mark J. Smyth · Blood · 1999 · 309 citations

, , +12

Edelfosine and perifosine induce selective apoptosis in multiple myeloma by recruitment of death receptors and downstream signaling molecules into lipid rafts

Consuelo Gajate, Faustino Mollinedo · Blood · 2006 · 277 citations · Full text

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The antitumor ether lipid ET-18-OCH3 induces apoptosis through translocation and capping of Fas/CD95 into membrane rafts in human leukemic cells

Consuelo Gajate, Faustino Mollinedo · Blood · 2001 · 272 citations

, , +15