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The novel Akt inhibitor, perifosine, induces caspase-dependent apoptosis and downregulates P-glycoprotein expression in multidrug-resistant human T-acute leukemia cells by a JNK-dependent mechanism

Novel Akt InhibitorMedicineApoptosisImmunologyCell DeathImmune Checkpoint InhibitorImmunotherapyPharmacologyP-glycoprotein ExpressionCell SignalingCaspase-dependent Apoptosis