A M Martelli

Suppression of PTEN function increases breast cancer chemotherapeutic drug resistance while conferring sensitivity to mTOR inhibitors

Linda S. Steelman, Patrick M. Navolanic, Melissa L. Sokolosky et al. · Oncogene · 2008 · 171 citations · Full text

Medicine, Cancer Biology, Oncology +14

The novel Akt inhibitor, perifosine, induces caspase-dependent apoptosis and downregulates P-glycoprotein expression in multidrug-resistant human T-acute leukemia cells by a JNK-dependent mechanism

Francesca Chiarini, Montse Solé, Sara Mongiorgi et al. · Leukemia · 2008 · 132 citations · Full text

Life Sciences, Oncology, Pharmacology +17

Proapoptotic activity and chemosensitizing effect of the novel Akt inhibitor perifosine in acute myelogenous leukemia cells

Verónica Papa, Pier Luigi Tazzari, Francesca Chiarini et al. · Leukemia · 2007 · 105 citations · Full text

Medicine, Oncology, Pharmacology +16

The phosphoinositide 3-kinase/Akt pathway regulates cell cycle progression of HL60 human leukemia cells through cytoplasmic relocalization of the cyclin-dependent kinase inhibitor p27Kip1 and control of cyclin D1 expression

Alessandra Cappellini, Giovanna Tabellini, Marina Zweyer et al. · Leukemia · 2003 · 85 citations · Full text

Life Sciences, Cell Biology, Molecular Biology +17

Cytotoxic activity of the casein kinase 2 inhibitor CX-4945 against T-cell acute lymphoblastic leukemia: targeting the unfolded protein response signaling

Francesca Buontempo, Ester Orsini, Leila R. Martins et al. · Leukemia · 2013 · 81 citations · Full text

Medicine, Cancer Biology, Oncology +16