Irina Mantovani

The novel Akt inhibitor, perifosine, induces caspase-dependent apoptosis and downregulates P-glycoprotein expression in multidrug-resistant human T-acute leukemia cells by a JNK-dependent mechanism

Francesca Chiarini, Montse Solé, Sara Mongiorgi et al. · Leukemia · 2008 · 132 citations · Full text

Life Sciences, Oncology, Pharmacology +17

Synergistic induction of apoptosis in human leukemia T cells by the Akt inhibitor perifosine and etoposide through activation of intrinsic and Fas-mediated extrinsic cell death pathways

Maria Nyåkern, Alessandra Cappellini, Irina Mantovani et al. · Molecular Cancer Therapeutics · 2006 · 89 citations

Life Sciences, Oncology, Pharmacology +17

Deguelin, A PI3K/AKT inhibitor, enhances chemosensitivity of leukaemia cells with an active PI3K/AKT pathway

Roberta Bortul, Pier Luigi Tazzari, Anna Maria Billi et al. · British Journal of Haematology · 2005 · 70 citations · Full text

Medicine, Oncology, Pharmacology +15

Caspase‐dependent cleavage of 170‐kDa P‐glycoprotein during apoptosis of human T‐lymphoblastoid CEM cells

Irina Mantovani, Alessandra Cappellini, Pier Luigi Tazzari et al. · Journal of Cellular Physiology · 2006 · 47 citations

Medicine, Oncology, Pharmacology +17

Detection of serine 473 phosphorylated Akt in acute myeloid leukaemia blasts by flow cytometry

Pier Luigi Tazzari, Alessandra Cappellini, Tiziana Grafone et al. · British Journal of Haematology · 2004 · 42 citations · Full text

Medicine, Cell Biology, Hematology +13