Modifiers of C9orf72 dipeptide repeat toxicity connect nucleocytoplasmic transport defects to FTD/ALS

Ana Jovičić, Jérôme Mertens, Steven Boeynaems, +12

Nature Neuroscience

Nucleocytoplasmic Transport DefectsAmyotrophic Lateral SclerosisBiochemistryNatural SciencesMolecular Biology +2

Targeted degradation of sense and antisense <i>C9orf72</i> RNA foci as therapy for ALS and frontotemporal degeneration

Clotilde Lagier‐Tourenne, Michael W. Baughn, Frank Rigo, +27

Proceedings of the National Academy of Sciences

Neurodegenerative DiseasesAmyotrophic Lateral SclerosisSporadic AlsChromosome 9Genetics +11

Gain of Toxicity from ALS/FTD-Linked Repeat Expansions in C9ORF72 Is Alleviated by Antisense Oligonucleotides Targeting GGGGCC-Containing RNAs

Jie Jiang, Qiang Zhu, Tania F. Gendron, +38

Neuron

Natural SciencesAls/ftd-linked Repeat ExpansionsMolecular BiologyLong Non-coding RnaC9orf72 Is +3

SRSF1-Regulated Alternative Splicing in Breast Cancer

Olga Anczuków, Martin Akerman, Antoine Cléry, +9

Molecular Cell

Transcriptional RegulationSrsf1-regulated Alternative SplicingCancer Cell BiologyBreast CancerCancer Genetics +4

HITS-CLIP and Integrative Modeling Define the Rbfox Splicing-Regulatory Network Linked to Brain Development and Autism

Sebastien M. Weyn‐Vanhentenryck, Aldo Mele, Qinghong Yan, +10

Cell Reports

Defining the regulatory network of the tissue-specific splicing factors Fox-1 and Fox-2

Chaolin Zhang, Zuo‐Feng Zhang, John C. Castle, +4

Genes & Development

ALS-causative mutations in FUS/TLS confer gain and loss of function by altered association with SMN and U1-snRNP

Shuying Sun, Shuo‐Chien Ling, Jinsong Qiu, +13

Nature Communications

C9ORF72 GGGGCC repeat-associated non-AUG translation is upregulated by stress through eIF2α phosphorylation

Weiwei Cheng, Shaopeng Wang, Alexander A. Mestre, +8

Nature Communications

Translational profiling identifies a cascade of damage initiated in motor neurons and spreading to glia in mutant SOD1-mediated ALS

Shuying Sun, Ying Sun, Shuo‐Chien Ling, +11

Proceedings of the National Academy of Sciences

SF2/ASF autoregulation involves multiple layers of post-transcriptional and translational control

Shuying Sun, Zuo‐Feng Zhang, Rahul Sinha, +2

Nature Structural & Molecular Biology

Sf2/asf AutoregulationTranscriptional RegulationSignal TransductionSignaling PathwayCell Regulation +8