Melinda S. Moynihan

Effects of quinolone derivatives on eukaryotic topoisomerase II. A novel mechanism for enhancement of enzyme-mediated DNA cleavage

Megan J. Robinson, Barbara A. Martin, Thomas D. Gootz et al. · Journal of Biological Chemistry · 1991 · 145 citations · Full text

Medicine, Molecular Biology, Pharmacology +15

Drug features that contribute to the activity of quinolones against mammalian topoisomerase II and cultured cells: correlation between enhancement of enzyme-mediated DNA cleavage in vitro and cytotoxic potential

Sarah H. Elsea, Paul R. McGuirk, Thomas D. Gootz et al. · Antimicrobial Agents and Chemotherapy · 1993 · 64 citations · Full text

Medicine, Molecular Biology, Pharmacology +14

Discovery of Potent, Nonsteroidal, and Highly Selective Glucocorticoid Receptor Antagonists

B. Paul Morgan, Andrew G. Swick, Diane M. Hargrove et al. · Journal of Medicinal Chemistry · 2002 · 60 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Placement of alkyl substituents on the C-7 piperazine ring of fluoroquinolones: dramatic differential effects on mammalian topoisomerase II and DNA gyrase

Thomas D. Gootz, Paul R. McGuirk, Melinda S. Moynihan et al. · Antimicrobial Agents and Chemotherapy · 1994 · 37 citations

Medicine, Medicinal Chemistry, Pharmacology +13

Discovery of Potent, Non-Steroidal and Highly Selective Glucocorticoid Receptor Antagonists with Anti-Obesity Activity

B. Paul Morgan, Kevin Liu, Deepak Dalvie et al. · Letters in Drug Design & Discovery · 2004 · 15 citations

Pharmacy, Medicinal Chemistry, Pharmacology +13