Isozyme-nonselective N-Substituted Bipiperidylcarboxamide Acetyl-CoA Carboxylase Inhibitors Reduce Tissue Malonyl-CoA Concentrations, Inhibit Fatty Acid Synthesis, and Increase Fatty Acid Oxidation in Cultured Cells and in Experimental Animals

H. James Harwood, Stephen F. Petras, Lorraine D. Shelly, +13

Journal of Biological Chemistry

Discovery of a novel series of 6-azauracil-based thyroid hormone receptor ligands: potent, TRβ subtype-selective thyromimetics

Robert L. Dow, Steven R. Schneider, Ernest S. Paight, +19

Bioorganic & Medicinal Chemistry Letters

Molecular PharmacologyMedicinal ChemistryNovel SeriesBiochemistryMedicine +5

Exenatide does not evoke pancreatitis and attenuates chemically induced pancreatitis in normal and diabetic rodents

Krystyna Tatarkiewicz, Pam Smith, Emmanuel J. Sablan, +10

American Journal of Physiology-Endocrinology and Metabolism

Gastrointestinal PharmacologyImmunologyGastroenterologyPathologyPancreas Transplantation +15

GLUT4 Overexpression in <i>db/db</i> Mice Dose-Dependently Ameliorates Diabetes But Is Not a Lifelong Cure

Joseph T. Brozinick, Scott C. McCoid, Thomas Reynolds, +5

Diabetes

Lifelong CureGlut4 OverexpressionImmunologyGlucose ToleranceInsulin Signaling +18

Discovery of Potent, Nonsteroidal, and Highly Selective Glucocorticoid Receptor Antagonists

B. Paul Morgan, Andrew G. Swick, Diane M. Hargrove, +7

Journal of Medicinal Chemistry

Medicinal ChemistryBiochemistryFunctional SelectivityMedicineNatural Sciences +11

Pharmacological Characterization of Apraglutide, a Novel Long-Acting Peptidic Glucagon-Like Peptide-2 Agonist, for the Treatment of Short Bowel Syndrome

Diane M. Hargrove, Sudarkodi Alagarsamy, Glenn Croston, +12

Journal of Pharmacology and Experimental Therapeutics

Bioluminescent imaging in induced mouse models of endometriosis reveals differences in four model variations

Ashley Dorning, Priya Dhami, Kavita Panir, +7

Disease Models & Mechanisms

GynecologyPathologyMenstrual CycleReproductive EndocrinologyTissue Imaging +17

An Arginine-Deficient Diet in Humans Does Not Evoke Hyperammonemia or Orotic Aciduria

Gale P. Carey, Zane Kime, Quinton R. Rogers, +4

Journal of Nutrition

NutritionHypertensionMetabolic SyndromeNutrient PhysiologyMetabolic Disorder +11

Synthesis and Pharmacological Characterization of Novel Glucagon-like Peptide-2 (GLP-2) Analogues with Low Systemic Clearance

Kazimierz Wiśniewski, Javier Sueiras-Diaz, Guangcheng Jiang, +19

Journal of Medicinal Chemistry

Analogues 69Molecular PharmacologyLow Systemic ClearancePharmacological CharacterizationNew Analogues +13

Glucose-dependent action of glucagon-like peptide-1(7-37) in vivo during short- or long-term administration

Diane M. Hargrove, Nancy A. Nardone, Lorna M. Persson, +2

Metabolism

BiochemistryPhysiologyDiabetesLong-term AdministrationEndocrinology +6