Paul Galatsis

Leucine-rich Repeat Kinase 2 (LRRK2) Pharmacological Inhibition Abates α-Synuclein Gene-induced Neurodegeneration

João Paulo Lima Daher, Hisham Abdelmotilib, Xianzhen Hu et al. · Journal of Biological Chemistry · 2015 · 204 citations · Full text

Neurodegenerative Diseases, Molecular Neuroscience, Cell Death +12

Discovery and Preclinical Profiling of 3-[4-(Morpholin-4-yl)-7 <i>H</i> -pyrrolo[2,3- <i>d</i> ]pyrimidin-5-yl]benzonitrile (PF-06447475), a Highly Potent, Selective, Brain Penetrant, and in Vivo Active LRRK2 Kinase Inhibitor

Jaclyn L. Henderson, Bethany L. Kormos, Matthew M. Hayward et al. · Journal of Medicinal Chemistry · 2014 · 178 citations · Full text

LRRK2 inhibitors induce reversible changes in nonhuman primate lungs without measurable pulmonary deficits

Marco A. S. Baptista, Kalpana Merchant, Ted Barrett et al. · Science Translational Medicine · 2020 · 123 citations

4-Hydroxy-2,2,6,6-tetramethylpiperidine-1-oxyl (Tempol) Inhibits Peroxynitrite-Mediated Phenol Nitration

Richard T. Carroll, Paul Galatsis, Susan Borosky et al. · Chemical Research in Toxicology · 2000 · 99 citations

Nitrosophenol Products, Biochemistry, Reactive Nitrogen Specie +11

Application of stable isotope labeled glutathione and rapid scanning mass spectrometers in detecting and characterizing reactive metabolites

Abdul Mutlib, Wing Lam, Jim Atherton et al. · Rapid Communications in Mass Spectrometry · 2005 · 76 citations

Metabolomic Profiling, Gas Chromatography, Bioanalysis +18