Iris K. L. Tan

Bax dimerizes via a symmetric BH3:groove interface during apoptosis

Grant Dewson, Stephen Ma, Paul Frederick et al. · Cell Death and Differentiation · 2011 · 183 citations · Full text

Symmetric Bh3, Cell Interaction, Apoptosis +5

VDAC2 enables BAX to mediate apoptosis and limit tumor development

Hui San Chin, Xiang Li, Iris K. L. Tan et al. · Nature Communications · 2018 · 182 citations · Full text

Bax targets mitochondria by distinct mechanisms before or during apoptotic cell death: a requirement for VDAC2 or Bak for efficient Bax apoptotic function

Thanh Ngoc Nguyen, Iris K. L. Tan, Robert L. Ninnis et al. · Cell Death and Differentiation · 2014 · 128 citations · Full text

Distinct Mechanisms, Mitophagy, Mitochondrial Function +11

Parkin inhibits BAK and BAX apoptotic function by distinct mechanisms during mitophagy

Jonathan P. Bernardini, Jason M. Brouwer, Iris K. L. Tan et al. · The EMBO Journal · 2018 · 107 citations · Full text

Distinct Mechanisms, Mitophagy, Cell Autophagy +9

BAK core dimers bind lipids and can be bridged by them

Angus D. Cowan, Nicholas A. Smith, Jarrod J. Sandow et al. · Nature Structural & Molecular Biology · 2020 · 66 citations

Proteinlipid Interaction, Biochemistry, Bak Core Dimers +6