Bax dimerizes via a symmetric BH3:groove interface during apoptosis

Grant Dewson, Stephen Ma, Paul Frederick, +4

Cell Death and Differentiation

Symmetric Bh3Cell InteractionApoptosisMolecular BiologyCell Death +3

VDAC2 enables BAX to mediate apoptosis and limit tumor development

Hui San Chin, Xiang Li, Iris K. L. Tan, +24

Nature Communications

Bax targets mitochondria by distinct mechanisms before or during apoptotic cell death: a requirement for VDAC2 or Bak for efficient Bax apoptotic function

Thanh Ngoc Nguyen, Iris K. L. Tan, Robert L. Ninnis, +6

Cell Death and Differentiation

Distinct MechanismsMitophagyMitochondrial FunctionApoptosisImmunology +9

Parkin inhibits BAK and BAX apoptotic function by distinct mechanisms during mitophagy

Jonathan P. Bernardini, Jason M. Brouwer, Iris K. L. Tan, +9

The EMBO Journal

Distinct MechanismsMitophagyCell AutophagySignal TransductionApoptosis +7

BAK core dimers bind lipids and can be bridged by them

Angus D. Cowan, Nicholas A. Smith, Jarrod J. Sandow, +15

Nature Structural & Molecular Biology

Proteinlipid InteractionBiochemistryBak Core DimersNatural SciencesMolecular Biology +4

Conversion of Bim-BH3 from Activator to Inhibitor of Bak through Structure-Based Design

Jason M. Brouwer, Ping Lan, Angus D. Cowan, +16

Molecular Cell

BiochemistryMedicineStructure-based DesignPharmacologyPharmaceutical Chemistry +1

Dissociation of Bak α1 helix from the core and latch domains is required for apoptosis

Amber E. Alsop, Stephanie C. Fennell, Ray C. Bartolo, +3

Nature Communications

Assaying Epitope ExposureApoptosisMolecular BiologyCell DeathCell Death Mechanisms +16

BAK α6 permits activation by BH3-only proteins and homooligomerization via the canonical hydrophobic groove

Xiang Li, Iris K. L. Tan, Colin Hockings, +5

Proceedings of the National Academy of Sciences

Dynamic reconfiguration of pro‐apoptotic BAK on membranes

Jarrod J. Sandow, Iris K. L. Tan, Shashank Masaldan, +11

The EMBO Journal

Membrane BiologyDynamic ReconfigurationMembrane SystemMembrane Formation

Mitochondrial E3 ubiquitin ligase MARCHF5 controls BAK apoptotic activity independently of BH3-only proteins

Allan Shuai Huang, Hui San Chin, Boris Reljić, +7

Cell Death and Differentiation

Bak Apoptotic ActivitySignal TransductionMitochondrial FunctionMedicineNatural Sciences +8