Prion-like behaviour and tau-dependent cytotoxicity of pyroglutamylated amyloid-β

Justin Nussbaum, Stephan Schilling, Holger Cynis, +15

Nature

Neurodegenerative DiseasesBiochemistryPrion-like BehaviourDegenerative PathologyPrion Disease +3

Mechanism of amyloid plaque formation suggests an intracellular basis of Aβ pathogenicity

Ralf P. Friedrich, Katharina Tepper, Raik Rönicke, +5

Proceedings of the National Academy of Sciences

Microglia Cells Protect Neurons by Direct Engulfment of Invading Neutrophil Granulocytes: A New Mechanism of CNS Immune Privilege

Jens Neumann, Steven Sauerzweig, Raik Rönicke, +5

Journal of Neuroscience

ImmunologyCell DeathCell CultureInnate ImmunityPmn Engulfment +20

Early neuronal dysfunction by amyloid β oligomers depends on activation of NR2B-containing NMDA receptors

Raik Rönicke, Marina Mikhaylova, Sabine Rönicke, +6

Neurobiology of Aging

Amyloid β OligomersSynaptic PlasticityNeurodegenerative DiseasesMolecular NeuroscienceSynaptic Transmission +8

Selective Hippocampal Neurodegeneration in Transgenic Mice Expressing Small Amounts of Truncated Aβ Is Induced by Pyroglutamate–Aβ Formation

Anca Alexandru, Wolfgang Jagla, Sigrid Graubner, +15

Journal of Neuroscience

Synaptic TransmissionCell DeathPosttranslational Amyloid-βSynaptic SignalingSocial Sciences +20

N‐Terminal pyroglutamate formation of Aβ38 and Aβ40 enforces oligomer formation and potency to disrupt hippocampal long‐term potentiation

Dagmar Schlenzig, Raik Rönicke, Holger Cynis, +7

Journal of Neurochemistry

Danish DementiaSynaptic TransmissionNeurochemical BiomarkersSynaptic SignalingSocial Sciences +23

Molecular basis of β-amyloid oligomer recognition with a conformational antibody fragment

Isabel Morgado, Karin Wieligmann, Magdalena Bereza, +16

Proceedings of the National Academy of Sciences

K‐Lysine acetyltransferase 2a regulates a hippocampal gene expression network linked to memory formation

Roman M. Stilling, Raik Rönicke, Eva Benito, +14

The EMBO Journal

Synaptic PlasticityMolecular NeuroscienceK‐lysine Acetyltransferase 2AMemoryNeuroscience +7

Structural Basis of β‐Amyloid‐Dependent Synaptic Dysfunctions

Christian Haupt, Jörg Leppert, Raik Rönicke, +7

Angewandte Chemie International Edition

Combining Independent Drug Classes into Superior, Synergistically Acting Hybrid Molecules

Andreas Müller‐Schiffmann, Julia März‐Berberich, Aksana Andreyeva, +17

Angewandte Chemie International Edition

Combinatorial ChemistryDrug TargetDrug SelectionPeptide EngineeringMolecular Biology +19